Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

A simple, sensitive and repeatable DO-single cell Raman spectroscopy method is developed to quantify the inhibitory activity of anticancer drugs on cancer cell metabolism. The IC values obtained from A549 cells incubated with cisplatin and taxol are comparable with results of CCK-8 and ATP luminescent cell viability assays.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d1cc06857aDOI Listing

Publication Analysis

Top Keywords

anticancer drugs
8
cell raman
8
raman spectroscopy
8
determination values
4
values anticancer
4
drugs cells
4
cells single
4
cell
4
single cell
4
spectroscopy simple
4

Similar Publications

Nonsmall cell lung cancer (NSCLC) with SMARCA4 deficiency represents a rare subset of lung tumors characterized by early metastasis, poor response to chemotherapy, and unfavorable prognosis. Established therapy strategies for SMARCA4-deficient NSCLC remain elusive. While immune checkpoint inhibitors have been proposed as a potential solution, their efficacy remains uncertain.

View Article and Find Full Text PDF

The neuroprotective potential of tyrosine kinase inhibitors (TKIs), potent anticancer drugs, was verified against various neurodegenerative insults, but not Huntington's disease (HD). These promising outcomes were due to their ability to modulate various intracellular signalling pathways. Hence, the current study aimed to evaluate the neuroprotective effects of lapatinib and pazopanib in the 3-nitropropionic (3-NP)-induced HD model in rats.

View Article and Find Full Text PDF

Isatin (1-indole-2,3-dione) is a privileged nitrogen-containing heterocyclic framework that has received considerable attention in anticancer drug discovery owing to its general biological behavior and structural diversity. This review focuses on isatin-heterocyclic hybrids as a valuable model in the development of new anti-cancer drugs that may reduce side effects and help overcome drug resistance, discussing their synthetic approaches and mechanism of action as apoptosis induction through kinase inhibition. With various chemical modifications, isatin had an excellent ability to build powerful isatin hybrids and conjugates targeting multiple oncogenic pathways.

View Article and Find Full Text PDF

Thunb is endogenous to Southeast Asia and traditionally used for the treatment of bacterial and viral infections. Previous studies reported various pharmacological activities, including cytotoxic activity. The aim of this work was to identify phytoconstituents of the ethanolic extract of aerial parts using extensive 1D- and 2D-NMR analysis and HR-MS.

View Article and Find Full Text PDF

An Approach to Drug Discovery via Ethnopharmacology and Sustainable Agriculture.

Curr Drug Discov Technol

September 2025

Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.

Ethnopharmacology is the study of traditional medicinal knowledge and its application in modern drug discovery. It combines ethnobotanical insights with scientific research to identify bio-active compounds with therapeutic potential. Sustainable agriculture refers to farming practices that maintain ecological balance, support biodiversity, and ensure the long-term availability of resources.

View Article and Find Full Text PDF