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The precise estimation of geodetic parameters using single- and double-differenced SLR observations is investigated. While the differencing of observables is a standard approach for the GNSS processing, double differences of simultaneous SLR observations are practically impossible to obtain due to the SLR basic principle of observing one satellite at a time. Despite this, the availability of co-located SLR telescopes and the use of the alternative concept of allow the forming of SLR differences under certain assumptions, thus enabling the use of these processing strategies. These differences are in principle almost free of both, satellite- and station-specific error sources, and are shown to be a valuable tool to obtain relative coordinates and range biases, and to validate local ties. Tested with the two co-located SLR telescopes at the Geodetic Observatory Wettzell (Germany) using SLR observations to GLONASS and LAGEOS, the developed differencing approach shows that it is possible to obtain single- and double-difference residuals at the millimetre level, and that it is possible to estimate parameters, such as range biases at the stations and the local baseline vector with a precision at the millimetre level and an accuracy comparable to traditional terrestrial survey methods. The presented SLR differences constitute a valuable alternative for the monitoring of the local baselines and the estimation of geodetic parameters.
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http://dx.doi.org/10.1007/s00190-021-01588-4 | DOI Listing |
Ophthalmol Sci
July 2025
Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Purpose: To investigate global longitudinal structure-function (SF) relationships between macular ganglion cell complex (GCC) thickness and central visual field (VF) mean deviation (MD) rates of change using a Bayesian joint bivariate longitudinal model.
Design: Prospective cohort study.
Participants: One hundred seventeen eyes from 117 patients with glaucoma with central damage or moderate to advanced glaucoma were included.
J Allergy Clin Immunol Pract
September 2025
Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado, USA. Electronic address:
Background: Several real-world cohorts and numerous case reports investigating benralizumab outcomes in eosinophilic granulomatosis with polyangiitis have been published. These studies complement the limited clinical trial data available by providing early insights on benralizumab use in a broader, real-world population.
Objective: The objective of this systematic literature review (SLR) was to provide an overview of the real-world outcomes of benralizumab in EGPA.
Curr Med Res Opin
September 2025
Merck & Co., Inc., BARDS Epidemiology, Rahway, NJ, USA.
Objective: Molnupiravir (MOV), an oral antiviral, is prescribed to treat adult patients with mild-to-moderate COVID-19 at risk of progressing to severe disease. Previous systematic literature reviews (SLRs) have evaluated the effectiveness of MOV in the general population; however, evidence on high-risk population is lacking. This SLR assessed the real-world effectiveness of MOV for reducing the progression to severe COVID-19 outcomes in clinical settings, including high-risk or special populations (such as patients with type 2 diabetes, chronic respiratory diseases, immunocompromised conditions, older adults, and nursing home residents) who have limited alternative COVID-19 treatment options.
View Article and Find Full Text PDFJ Phys Condens Matter
September 2025
Physics and Astronomy, UVic, 3800 Finnerty Road, Victoria, British Columbia, V8P 5C2, CANADA.
We report measurements of the normal-state and superconducting properties of thin-film NbTiN usingLi-detected nuclear magnetic resonance (-NMR). In these experiments, radioactiveLiprobes were implanted 21 nm below the surface of a NbTiN(91 nm) film in NbTiN/(91 nm)/AlN(4 nm)/Nb and its NMR response recorded (viaLi's-emissions) between 4.6 K and and 270 K in a 4.
View Article and Find Full Text PDFCamb Prism Coast Futur
June 2025
Institute for Marine and Atmospheric Research Utrecht, Utrecht University, Utrecht, The Netherlands.
While adapting to future sea-level rise (SLR) and its hazards and impacts is a multidisciplinary challenge, the interaction of scientists across different research fields, and with practitioners, is limited. To stimulate collaboration and develop a common research agenda, a workshop held in June 2024 gathered 22 scientists and policymakers working in the Netherlands. Participants discussed the interacting uncertainties across three different research fields: sea-level projections, hazards and impacts, and adaptation.
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