Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Therapeutic doses of anticoagulation have been administered to patients with coronavirus-19 disease (Covid-19) without thromboembolism, although there is a lack of robust evidence supporting this practice.
Study Question: To compare outcomes between patients admitted to the hospital for Covid-19 who received full-dose anticoagulation purely for the indication of Covid-19 and patients who received prophylactic doses of anticoagulation.
Study Design: This is a multicenter retrospective cohort study, including 7 community hospitals in Michigan. Patients were >18 years of age, confirmed positive for Covid-19 by polymerase chain reaction, and admitted to the hospital between March 10 and May 3, 2020. Exposed group: Patients receiving therapeutic dose anticoagulation for Covid-19 for any duration excluding clinically evident venous thromboembolism, atrial fibrillation, and myocardial infarction; control group: Patients receiving prophylactic anticoagulation. Propensity score matching was used to adjust for the nonrandomized nature of the study.
Measures And Outcomes: The primary endpoint: 30-day in-hospital mortality. Secondary endpoints: intubation, length of hospital stay, and readmissions in survivors.
Results: A total of 115 exposed and 115 control patients were analyzed. Rates of 30-day in-hospital mortality were similar (exposed: 33.0% vs. control: 28.7%). Controlling for institution, there was no significant association between treatment and 30-day in-hospital mortality (hazard ratio: 0.63; 95% confidence interval: 0.37-1.06). Survivors had statistically similar length of hospital stay and readmission rates.
Conclusions: We found no difference in mortality in patients with Covid-19 without clinically evident venous thromboembolism, atrial fibrillation, and myocardial infarction who received therapeutic versus prophylactic doses of anticoagulation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MJT.0000000000001462 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Paediatric scoring systems in congenital heart surgery: evaluating predictive accuracy for major adverse events.
Cardiol Young
September 2025
Department of Anesthesiology and Reanimation, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Objectives: This study aimed to evaluate the predictive accuracy of Paediatric Risk of Mortality-III, Paediatric Index of Mortality-II, and Paediatric Logistic Organ Dysfunction scoring systems for major adverse events following congenital heart surgery.
Methods: This prospective observational study included patients under 18 years of age who were admitted to the ICU for at least 24 hours postoperatively following congenital heart surgery. Major adverse events were defined as a composite of 30-day mortality, ICU readmission, reintubation, acute neurologic events, requirement for extracorporeal membrane oxygenation, cardiac arrest requiring cardiopulmonary resuscitation, need for a permanent pacemaker, acute kidney injury, or unplanned reoperation.
Patient Characteristics Associated with 30-Day Readmission to a Pediatric Cardiac Center.
Pediatr Cardiol
September 2025
Division of Cardiology, Children's National Hospital, 111 Michigan Ave, Washington, DC, 20010, USA.
Patients with acquired and congenital heart disease (CHD) are at higher risk of hospitalization. Despite quality improvement (QI) initiatives, many patients experience readmission soon after discharge. We aimed to identify risk factors for 30-day readmission and hypothesized that direct discharge from the cardiac intensive care unit (CICU) is associated with an increased readmission rate.
View Article and Find Full Text PDFPenetrating extremity injuries in a large Scandinavian Level-1 trauma center: a 4-year analysis of imaging methods, mechanisms of injury and clinical outcome.
Eur J Orthop Surg Traumatol
September 2025
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Background: To analyze penetrating extremity injuries at a Scandinavian urban Level-1 trauma center regarding incidence, mechanism of injury, imaging approach and clinical outcome.
Methods: A retrospective study (2013-2016) of penetrating injuries to the extremities based on a Trauma Registry. Retrieved variables included patient demographics, injury characteristics, time to CT and 30-day morbidity.
Comparative outcomes of self-expanding stenting in symptomatic MCA-M2 versus MCA-M1 segment stenosis.
J Neurointerv Surg
September 2025
Department of Neurointerventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Background: The outcomes of self-expanding stenting for symptomatic middle cerebral artery (MCA) M2 segment stenosis remain unclear. We aimed to analyze whether the safety and efficacy of M2 and M1 segment stenting procedures differ.
Methods: This multicenter retrospective cohort study analyzed data from three stroke centers involving patients who underwent self-expanding stent placement for symptomatic M1 or M2 stenosis between January 2017 and August 2024.
Prehospital 12-lead ECG and outcomes in acute coronary syndrome.
Heart
September 2025
Kingston University, London, UK.
Importance/background: The 12-lead ECG is recommended in clinical guidelines for prehospital assessment of patients with suspected acute coronary syndrome (ACS) presenting to Emergency Medical Services (EMS).
Objectives: To determine prehospital ECG (PHECG) utilisation since UK national rollout of primary percutaneous coronary intervention, and whether this is associated with clinical outcomes in patients with ACS.
Design: Population-based, linked cohort study using Myocardial Ischaemia National Audit Project data from 1 January 2010 to 31 December 2017, related to patients with ACS conveyed by the EMS to hospital in England and Wales.