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Clarithromycin (CYP inhibitor) can be used instead of azithromycin for nontuberculous mycobacteria therapy in patients requiring CYP substrates to mitigate rifampin's CYP induction. We found no differences in adverse events (10/13 vs 14/17; = .73), drug intolerability (1/5 vs 4/11; = 1), or 90-day mortality (0/13 vs 1/17; = 1) in patients receiving clarithromycin vs azithromycin.
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http://dx.doi.org/10.1093/ofid/ofab582 | DOI Listing |
J Med Chem
September 2025
Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan 410013, China.
KasA and KasB are promising drug targets against and infectious nontuberculous mycobacteria, while most lead compounds are in the preclinical development stage. Herein, a platensimycin (PTM) analogue library consisting of 340 members was first screened to identify 46 PTM thioethers with superior activity compared to that of PTM against . Next, 19 PTM thioethers were chosen and semisynthesized from PTM oxirane (), together with seven PTM ether derivatives and 6-ido, 6-bromo-, and 6-thiocyanato PTM.
View Article and Find Full Text PDFInt J Infect Dis
September 2025
Goethe-University Frankfurt, University Hospital, Department of Medicine no. 2, Infectious Diseases. Electronic address:
Objectives: Disseminated nontuberculous mycobacterial disease (dNTMd) remains a rare but serious complication in people living with HIV (PLWH). This study aimed to assess whether dNTMd independently contributes to delayed CD4-cell recovery following antiretroviral therapy (ART) initiation.
Methods: This retrospective 1:3 single center case-control study analyzed patient data from 2004 to 2023.
J Dermatolog Treat
December 2025
Department of Dermatology, Hangzhou Third People's Hospital, Zhejiang, China.
Purpose: Sarcoidosis is a chronic, multisystem granulomatous disorder characterized histologically by non-caseating granulomas. Despite the availability of various therapeutic options, long-term disease control remains a significant clinical challenge.
Materials And Methods: We report the case of a 55-year-old female diagnosed with sarcoidosis.
Epidemiol Serv Saude
September 2025
Ministério da Saúde, Programa de Treinamento em Epidemiologia Aplicada aos Serviços do SUS, Brasília, DF, Brazil.
Report on a field investigation into the outbreak of skin infections by Mycobacterium abscessus subsp. abscessus following cosmetic procedures. A retrospective cohort study was conducted using secondary data from the Epidemiology Program Applied to SUS Services (EpiSUS) about the investigation conducted in 2022, in partnership with Paraguay's Field Epidemiology Training Program.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, China.
Unlabelled: This study aimed to investigate the epidemic status and distribution characteristics of drug-resistant in Urumqi. From January 2019 to July 2024, all sputum culture-positive strains were collected in Urumqi. Using the traditional solid-state proportion method for drug-sensitivity testing, we determined the resistance of to first-line antituberculosis (TB) drugs.
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