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http://dx.doi.org/10.1021/jacs.1c13632 | DOI Listing |
ASAIO J
June 2025
Department of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen University, Aachen, Germany.
The storing of dry-assembled and primed extracorporeal membrane oxygenation (ECMO) circuits is common practice and endorsed by the Extracorporeal Life Support Organization (ELSO) for up to 30 days. We conducted an anonymous survey among chief perfusionists in German neonatal and pediatric ECMO centers to identify key parameters of the actual clinical practices. Ten of 15 (67%) participating centers do not pre-assemble and pre-prime circuits in apprehension of future patients.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2025
Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka 560-0043, Japan.
Motile cilia are organelles found on many eukaryotic cells that play critical roles in development and fertility. Human CFAP298 has been implicated in the transport/assembly of ciliary dyneins, and defects in this protein cause primary ciliary dyskinesia. However, neither the exact function nor the structure of CFAP298 have been elucidated.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
April 2025
School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
Zirconium metal-organic frameworks (Zr-MOFs) exhibit a wide range of Zr cluster connectivities, from 3-connected to 12-connected, enabling diverse structural designs. However, odd-numbered connectivities, especially the 7-connected Zr-MOFs, are exceptionally rare due to geometric symmetry challenges. To address this, we developed a geometric pre-assembly strategy to achieve targeted cluster connectivity.
View Article and Find Full Text PDFJ Cell Biol
February 2025
Department of Biology, University of Washington, Seattle, WA, USA.
The plant corepressor TPL is recruited to diverse chromatin contexts, yet its mechanism of repression remains unclear. Previously, we leveraged the fact that TPL retains its function in a synthetic transcriptional circuit in the yeast model Saccharomyces cerevisiae to localize repressive function to two distinct domains. Here, we employed two unbiased whole-genome approaches to map the physical and genetic interactions of TPL at a repressed locus.
View Article and Find Full Text PDFJ Orthop Surg Res
September 2024
Department of Orthopedics, Kaohsiung Medical University Hospital, No.482, Shanming Rd., Siaogang Dist., Kaohsiung City, 812, Taiwan.
Background: Facilitating the healing process of injured anterior cruciate ligament (ACL) tissue is crucial for patients to safely return to sports. Stem cell derived exosomes have shown positive effects on enhancing the regeneration of injured tendons/ligaments. However, clinical application of exosomes in terms of storage and pre-assembly is challenging.
View Article and Find Full Text PDF