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http://dx.doi.org/10.1186/s12968-021-00836-y | DOI Listing |
NAR Genom Bioinform
September 2025
Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
The selective expression of genes is the basis of cellular and individual phenotypic differences, serving as a mediator in the causal pathways from genotypes to phenotypes. Single-cell differential expression analysis identifies distinct transcriptomic landscapes, but fails to establish causal relationships due to the presence of confounders. On the other hand, causal inference methods in population genetics such as Mendelian randomization often overlook the heterogeneity among cells and dynamic changes along trajectory.
View Article and Find Full Text PDFJ Cardiovasc Magn Reson
May 2025
Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois, USA; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; McCormick School of Engineering, Northwestern University, Evanston, Illinois
The 28th Annual Scientific Sessions of the Society for Cardiovascular Magnetic Resonance (SCMR) took place from January 29 to February 1, 2025, in Washington, D.C. SCMR 2025 brought together a diverse group of 1714 cardiologists, radiologists, scientists, and technologists from more than 80 countries to discuss emerging trends and the latest developments in cardiovascular magnetic resonance (CMR).
View Article and Find Full Text PDFFront Plant Sci
April 2025
Department of Biotechnology and Plant Breeding, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.
Chickpea ( L.), through a series of morphological, physiological, biochemical, and molecular changes, would tolerate abiotic stresses such as water deficiency. Accordingly, two separate experiments were conducted to investigate phytochemical and morphophysiological traits of various candidate chickpea genotypes in response to drought stress.
View Article and Find Full Text PDFCirc Genom Precis Med
June 2025
Erich & Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany (S.V., J.G., S.H., H.M., A.B.).
Background: Nonischemic cardiomyopathies are frequently caused by genetic mutations in about 100 different genes. The cardiomyopathy-associated gene encodes the intermediate filament protein desmin, which is important for the structural integrity of the cardiomyocytes.
Methods: Using a next-generation sequencing approach, we performed cascade screening of a previously identified heterozygous missense mutation (c.
Radiology
January 2025
From the Department of Radiology, University of Washington, UW Medical Center-Montlake, Seattle, Wash (D.M.); Department of Radiology, OncoRad/Tumor Imaging Metrics Core (TIMC), University of Washington, Seattle, Wash (D.M.); Department of Radiology and Imaging Sciences, Emory University, Atlanta, G
Artificial intelligence (AI) offers promising solutions for many steps of the cardiac imaging workflow, from patient and test selection through image acquisition, reconstruction, and interpretation, extending to prognostication and reporting. Despite the development of many cardiac imaging AI algorithms, AI tools are at various stages of development and face challenges for clinical implementation. This scientific statement, endorsed by several societies in the field, provides an overview of the current landscape and challenges of AI applications in cardiac CT and MRI.
View Article and Find Full Text PDF