Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
There is growing interest in the role of microorganisms in human health and disease, with evidence showing that new types of biotherapy using engineered bacterial therapeutics, including bacterial derivatives, can address specific mechanisms of disease. The complex interactions between microorganisms and metabolic/immunologic pathways underlie many diseases with unmet medical needs, suggesting that targeting these interactions may improve patient treatment. Using tools from synthetic biology and chemical engineering, non-pathogenic bacteria or bacterial products can be programmed and designed to sense and respond to environmental signals to deliver therapeutic effectors. This review describes current progress in biotherapy using live bacteria and their derivatives to achieve therapeutic benefits against various diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.addr.2021.114085 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metabolic rewiring and morphological adaptations drive bacterial strain-specific cadmium defense in the Yangtze River estuary.
Microbiol Res
September 2025
Key Laboratory of Marine Ecosystem Dynamics, Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou 310012, China.
Cadmium (Cd) contamination in coastal regions poses severe environmental risks, yet bacterial defense mechanisms against Cd remain poorly understood. This study unveils distinct tolerant strategies of two highly Cd-tolerant bacteria isolated from the Yangtze River estuary: Comamonas sp. Y49 and Aeromonas sp.
View Article and Find Full Text PDFGenital microbiota in infertile couples.
Reprod Biomed Online
May 2025
Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, University Hospital of Lausanne, Lausanne, Switzerland; Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Electronic address:
Research Question: What is the composition of bacterial communities at various genital sites and are there potential interactions between partners' microbiota?
Design: This observational study involved metagenomic analyses of samples collected from male and female partners of couples undergoing fertility treatment. Samples included vaginal and penile swabs, as well as follicular fluid and semen, which were analysed using next-generation sequencing.
Results: The bacterial community profiles of different genital tract niches were distinct, niche-specific compositions, with female samples predominantly featuring Lactobacillus species and male samples displaying greater microbial diversity, including genital-specific and skin-associated taxa.
Respiratory and gastrointestinal infections among Hajj pilgrims during the 2012-2025 seasons: A systematic review.
J Infect Public Health
September 2025
Department of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan 82911, Saudi Arabia; School of Medicine, Universidad Espiritu Santo, Samborondon 091952, Ecuador. Electronic address:
Introduction: Hajj is the largest annual mass gathering in the world, attracting more than 2 million pilgrims from 184 countries. Adverse climatic conditions and close proximity of pilgrims during Hajj rituals create a facilitating environment for the transmission of infectious agents, including multi-drug resistant organisms. Although, several individual reports have been published on specific type of infections, there is a paucity of published work reflecting the overall picture of the prevalence of pathogenic infections during Hajj.
View Article and Find Full Text PDFIdentification of a Pseudomonas brassicacearum strain as a potential biocontrol agent against clubroot in cruciferous plants through endophytic bacterial community analysis and culture-dependent isolation.
Pest Manag Sci
September 2025
College of Plant Protection, Shenyang Agricultural University, Shenyang, China.
Background: Clubroot, caused by Plasmodiophora brassicae, significantly impacts cruciferous crop production worldwide. Biocontrol is an environmentally friendly and promising approach for clubroot management. Endophytic bacteria are known for their ability to promote plant growth and induce resistance against plant diseases.
View Article and Find Full Text PDFUse of Electrolysed Water as Disinfection Technology in Front of Various Microorganisms and SARS-COV-2.
Food Environ Virol
September 2025
REDOLí Research Group, Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat de Valencia, Valencia, Spain.
The global emergence of SARS-CoV-2 has highlighted the urgent need for effective disinfection strategies to mitigate virus transmission. Electrolyzed water (EW), an eco-friendly and cost-effective biocidal agent, has garnered attention for its broad-spectrum antimicrobial activity. This study evaluates the virucidal, bactericidal, and fungicidal capacities of EW with diverse pH, with a focus on its effectiveness against SARS-CoV-2 and other pathogens.
View Article and Find Full Text PDF