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Objective: In its aim to develop a model of an occupational safety and health management system (OSHMS) for MSMEs in Indonesia, this study seeks to explore crucial factors in relation to the implementation of such a system in MSMEs by conducting a review of previous studies on the topic.
Methods: This systematic review is an exploratory study from several online databases our using a combination of two keywords that refer to the population and exposure variables in the PROSPERO Approach by using the "AND" strategy. Each literature goes through selection based on PRISMA flow chart. A Critical Appraisal Skill Programme (CASP) checklist for risk of bias assessment was used for the evidence quality appraisal.
Result: From 37 papers, books, online books and local articles were selected, we identified pivotal factors in the implementation of OHSMS in MSMEs which can be classified into downstream factors (OSH training, commitment, risk management, and communication), middle stream factors (support from the third party), and upstream factors (the role of government).
Conclusion: Various pivotal factors in promoting OSH implementation at MSMEs can be seen as role of MSMEs actors (employer and employee); third party and government.
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http://dx.doi.org/10.1016/j.gaceta.2021.10.050 | DOI Listing |
Blood
September 2025
University of Illinois at Chicago, Chicago, Illinois, United States.
Hematopoietic stem cells (HSCs) responsible for blood cell production and their bone marrow regulatory niches undergo age-related changes, impacting immune responses and predisposing individuals to hematologic malignancies. Here, we show that the age-related alterations of the megakaryocytic niche and associated downregulation of Platelet Factor 4 (PF4) are pivotal mechanisms driving HSC aging. PF4-deficient mice display several phenotypes reminiscent of accelerated HSC aging, including lymphopenia, increased myeloid output, and DNA damage, mimicking physiologically aged HSCs.
View Article and Find Full Text PDFPLoS Pathog
September 2025
State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Hepatocyte nuclear factor 4 alpha (Hnf4α), a conserved nuclear receptor central to vertebrate liver development and metabolic regulation, emerges here as a pivotal immune regulator in teleosts against complex infectious threats. While its metabolic roles are well-established, Hnf4α's function in bacterial infection, viral infection, and bacterial-viral coinfection-major challenges in global aquaculture-remained uncharacterized. This study reveals that teleost Hnf4α acts as a dual-functional immune checkpoint, essential for combating Aeromonas salmonicida, grass carp reovirus (GCRV), and their coinfection.
View Article and Find Full Text PDFmBio
September 2025
Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture and Rural Affairs, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Unlabelled: Fungal degradation of cellulose facilitates the sustainable harnessing of biosphere energy and carbon cycling. is one of the basidiomycetes with the largest number of hydrolytic enzymes in its genome. The mycelium of degrades cellulose through the production of substantial amounts of cellulase, enabling the absorption of carbon sources and nutrients essential for fruiting body development.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 is a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomics, and thermal proteome profiling experiments, AP1G1, a pivotal protein involved in cellular endocytosis, was indiscriminately screened as a chaperone of SLC16A3.
View Article and Find Full Text PDFDrug Dev Res
September 2025
R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with "epidermal growth factor receptor (EGFR)" mutations playing a pivotal role in tumor progression and carcinogenesis. "Third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)," such as Osimertinib, have significantly improved treatment outcomes by overcoming resistance mechanisms like the T790M mutation. However, Osimertinib's clinical application is limited by cardiotoxicity concerns, necessitating safer alternatives.
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