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Background: Malposition of the sesamoids relative to the first metatarsal head may relate to intersesamoid crista underdevelopment or erosion. Using 3-dimensional models created from weightbearing CT (WBCT) scans, the current work examined crista volume and its relationship to first metatarsal pronation and sesamoid station.
Methods: Thirty-eight hallux valgus (HV) patients and 10 normal subjects underwent weightbearing or simulated WBCT imaging. The crista was outlined by the inferior articular surface, and a line was drawn to connect the lowest point of each sulcus on either side of the intersesamoidal crista throughout the length of the crista. The volume was calculated. Sesamoid station and first metatarsal pronation were calculated from the 3D reconstructions. The mean crista volumes between HV and normal patients were statistically compared, as were the crista volume and pronation angle between sesamoid stations.
Results: The mean crista volume in HV patients was 80.10 ± 35 mm and in normal subjects was 150.64 ± 24 mm, which differed significantly between the 2 groups ( < .001). Mean crista volumes were found to be statistically significantly different between the sesamoid stations ( < .001) with decreasing crista volumes significantly and strongly correlated with increasing sesamoid station ( = -0.80, < .001). There was no difference in the mean pronation angle between the 4 sesamoid stations ( = .37). The pronation angle was not associated with crista volume ( = .52).
Conclusion: HV patients have lower mean crista volume than normal patients. Crista volume is correlated with sesamoid station. Pronation of the first metatarsal was not associated with crista volume.
Clinical Relevance: Crista volume may offer an additional determinant for the severity of hallux valgus.
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http://dx.doi.org/10.1177/10711007211061363 | DOI Listing |
Zhongguo Zhen Jiu
August 2025
School of Acupuncture-Moxibustion and Tuina, Tianjin University of TCM.
Objective: To explore the neuroprotective effect and underlying mechanism of acupuncture (acupuncture for regaining consciousness and opening orifices) in the rat models of cerebral ischemia-reperfusion injury (CIRI) based on the p53 protein (p53)/solute carrier family 7 member 11 (SLC7A11)/glutathione peroxidase 4 (GPX4) signaling pathway.
Methods: Of 102 male Wistar rats, 20 rats were randomly collected as a sham-operation group. Using a modified external carotid artery filament insertion method, CIRI models were prepared by occluding the middle cerebral artery in the rest rats.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
June 2025
Department of Emergency, Kweichow Moutai Hospital, Renhuai, Renhuai 564500, Guizhou, China.
Objective: To investigate whether auraptene (AUR) exerts a protective effect on acute diquat (DQ)-induced liver injury in mice and explore its underlying mechanisms.
Methods: Forty SPF-grade healthy male C57BL/6 mice were randomly divided into normal control group (Control group), DQ poisoning model group (DQ group), AUR treatment group (DQ+AUR group), and AUR control group (AUR group), with 10 mice in each group. The DQ poisoning model was established via a single intraperitoneal injection of 40 mg/kg DQ aqueous solution (0.
Food Chem Toxicol
October 2025
Key Laboratory of Pathobiology (Yanbian University), State Ethnic Affairs Commission, Yanji, 133000, PR China; Research and Innovation Group of Yanbian University, Yanbian University Medical College, Yanji, 133000, PR China. Electronic address:
Context: Cervical cancer (CC) ranks as one of the most common types of malignant tumors affecting women. CDDO-Me is derived from oleanolic acid, a pentacyclic triterpenoid obtained by chemical structural modification, which has been shown anti-tumor effects.
Results: CC cell proliferation was decreased by CDDO-Me both in vitro and in vivo.
J Appl Physiol (1985)
August 2025
Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
The skeletal muscle mitochondrial network, composed of interconnected subsarcolemmal and intermyofibrillar mitochondria, is essential for oxygen-dependent energy transduction. Since high altitude is characterized by tissue hypoxia, this network may adapt by increasing its respiratory efficiency, but little is known about potential adaptations of the mitochondrial network in such an environment. We investigated the effects of high-altitude exposure on mitochondrial subcellular distribution, ultrastructure, respiratory control, and intrinsic respiratory capacity.
View Article and Find Full Text PDFInt J Biol Macromol
August 2025
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Key Laboratory of Liver and Kidney Diseases, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai
Ferroptosis is a regulated cell death pathway characterized by iron-dependent accumulation of lipid peroxides and distinct mitochondrial morphological alterations, including reduced volume, increased membrane density, elevated membrane potential, cristae loss, and outer membrane rupture. These features starkly contrast with those observed in apoptosis, autophagy, and necrosis. As the cellular energy hub and metabolic nexus, mitochondria play multifaceted regulatory roles in ferroptosis through their integration of metabolic networks and redox homeostasis.
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