Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: Osteonecrosis of the femoral head (ONFH) is a designated intractable disease (DID) in Japan. The Ministry of Health, Labour, and Welfare launched an online registry system for DIDs. We aimed to investigate the epidemiological characteristics of patients with ONFH using the DID database.
Methods: Data of patients with ONFH registered in the DID database between January 2004 and December 2013 were extracted. The incidence of new cases and distributions of sex, age, and associated risk factors were investigated. The prevalence of the two categories, 'steroid-associated' and 'alcohol-associated' risk factors, was estimated for each prefecture.
Results: New 15,049 cases of ONFH were investigated. The mean registration rate-corrected annual ONFH incidence per 100,000 individuals was 1.77. The male-to-female ratio was 1.33. Age distribution peaked in the 40s and 50s for male and 60s for female. The prevalence of steroid-associated ONFH was lower in males (28.6%) than in females (49.8%), while that of alcohol-associated ONFH was higher in males (47.2%) than in females (9.3%). No clear region was identified for the steroids. The incidence of alcohol-associated ONFH was significantly higher in Tokyo and Okinawa, regardless of sex.
Conclusions: Alcohol-associated ONFH incidence varies geographically across Japan, suggesting that it has regional characteristics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/mr/roab065 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of teriparatide and factors for the collapse of femoral head following femoral curved varus osteotomy.
J Hip Preserv Surg
July 2025
Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo 060-8638, Japan.
Osteonecrosis of the femoral head (ONFH) often leads to femoral head collapse, which makes joint preservation challenging. Although curved varus osteotomy (CVO) is an effective surgical method for joint preservation in young ONFH patients, there are some cases where it cannot prevent femoral head collapse. This research aims to evaluate the usefulness of teriparatide (TPD) in bone healing and preventing femoral head collapse in CVO-treated ONFH patients.
View Article and Find Full Text PDFA 5-Year Longitudinal Assessment of Quality of Life in Patients Who Have Osteonecrosis of the Femoral Head Undergoing Total Hip Arthroplasty: A Multicenter Study.
J Arthroplasty
July 2025
Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Suita, Japan.
Background: The effects of surgical treatment on the quality of life (QOL) of patients who have osteonecrosis of the femoral head (ONFH) have been rarely reported. This multicenter study aimed to elucidate the longitudinal QOL in patients who have ONFH undergoing total hip arthroplasty.
Methods: Self-assessment QOL questionnaires, including the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ), Oxford Hip Score (OHS), and 12-Item Short-Form Health Survey Version 2 (SF-12v2), were administered to 124 patients at 6 months, 1 year, 2 years, and 5 years postoperatively.
Updating Osteonecrosis of the Femoral Head.
Hip Pelvis
September 2023
Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
Article Synopsis
- Osteonecrosis of the femoral head (ONFH) involves bone death in the femoral head due to disrupted blood flow, primarily affecting young to middle-aged adults and often leading to hip replacement surgery.
- The condition's incidence is rising, particularly linked to the increased use of glucocorticoids for treating conditions like leukemia, organ transplant, and other diseases.
- The review outlines current knowledge on causes, progression, various stages, and treatment options for ONFH, including ARCO criteria for classifying cases associated with glucocorticoids and alcohol, along with updated staging and classification systems.
Less sclerotic microarchitecture pattern with increased bone resorption in glucocorticoid-associated osteonecrosis of femoral head as compared to alcohol-associated osteonecrosis of femoral head.
Front Endocrinol (Lausanne)
March 2023
Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Glucocorticoid usage and alcohol abuse are the most widely accepted risk factors for nontraumatic osteonecrosis of femoral head (ONFH). Despite distinct etiologies between glucocorticoid-associated ONFH (GONFH) and alcohol-associated ONFH (AONFH), little is known about the differences of the microarchitectural and histomorphologic characteristics between these subtypes of ONFH.
Purposes: To investigate bone microarchitecture, bone remodeling activity and histomorphology characteristics of different regions in femoral heads between GONFH and AONFH.
Geographical distribution of the associated factors of osteonecrosis of the femoral head, using the designated intractable disease database in Japan.
Mod Rheumatol
August 2022
Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, Osaka, Japan.
Objectives: Osteonecrosis of the femoral head (ONFH) is a designated intractable disease (DID) in Japan. The Ministry of Health, Labour, and Welfare launched an online registry system for DIDs. We aimed to investigate the epidemiological characteristics of patients with ONFH using the DID database.
View Article and Find Full Text PDF