A Five-Year Longitudinal Assessment of Quality of Life and Employment Status in Patients Who Have Osteonecrosis of the Femoral Head Undergoing Femoral Osteotomy: A Multicenter Study.

Background: The impact of femoral osteotomy on the quality of life (QOL) and employment status in patients who have osteonecrosis of the femoral head (ONFH) remains inadequately characterized. This multicenter study aimed to evaluate the longitudinal changes in QOL and employment status among patients who have ONFH undergoing femoral osteotomy.

Methods: There were 35 patients (18 men, 17 women; mean age 32 years) who underwent femoral osteotomy for ONFH included.

Characteristics of Osteonecrosis of the Femoral Head After COVID-19 Compared to Corticosteroid-Associated Osteonecrosis of the Femoral Head: A Multicenter, Large Database Study in Japan.

Background: Coronavirus disease 2019 (COVID-19) has been associated with systemic complications in addition to respiratory symptoms, including potential musculoskeletal disorders, such as osteonecrosis of the femoral head (ONFH). The aim of this study was to determine the difference between ONFH after COVID-19 and corticosteroid-associated ONFH using a large-scale ONFH database.

Methods: We analyzed 5,371 registered ONFH patients from a large multicenter Japanese database, identifying 20 patients (32 hips) who developed ONFH after COVID-19 (COVID-19 group).

Changes in Hip Arthroplasty Practice Decreased Dislocation Risk After Primary Arthroplasties Performed for Nontraumatic Osteonecrosis of the Femoral Head.

Background: Hip arthroplasty practices have evolved considerably over time. This nationwide multicenter follow-up cohort study of primary hip arthroplasties performed for nontraumatic osteonecrosis of the femoral head aimed to address the following question: Have demographic and operative variables, as well as follow-up outcomes (dislocation and need for reoperation), changed over time?

Methods: A total of 7,494 hip arthroplasties were analyzed, categorized into three 9-year periods based on the date of operation: the first (1996 to 2004, 1,403 hips), the second (2005 to 2013, 2,631 hips), and the third (2014 to 2022, 3,460 hips) periods.

Results: Demographic characteristics changed gradually over time, while operative variables shifted significantly.

Temporal Changes in the Age at Diagnosis of Osteonecrosis of the Femoral Head and Potential Associated Factors: A Multicenter Sentinel Monitoring System in Japan.

Background: In Japan, a multicenter sentinel monitoring system was implemented as a patient registry for osteonecrosis of the femoral head (ONFH). Although recent monitoring data suggest that the age at diagnosis of ONFH is increasing, it is unclear whether this trend is due to Japan's aging population. We aimed to evaluate the temporal trends in ONFH incidence by age group using other epidemiological data.

Radiographic Progression in the Pre-Radiographic Stage of Osteonecrosis of the Femoral Head.

Background: Early and accurate diagnosis of osteonecrosis of the femoral head (ONFH) is crucial for the success of joint-preserving treatments. Although multimodal diagnostic criteria, including radiographs, enhance diagnostic accuracy, they are limited in detecting preradiographic stages. Magnetic resonance imaging (MRI) is widely utilized; however, it is associated with the risk of overdiagnosis.

Comparison of the 2021 Association Research Circulation Osseous Classification System for Osteonecrosis of the Femoral Head and the Japanese Investigation Committee Classification System.

Background: The size and location of the necrotic area are important factors in predicting prognosis and determining treatment in patients who have osteonecrosis of the femoral head (ONFH). This study assessed the utility of the 2021 Association Research Circulation Osseous (ARCO) classification system, which is based on coronal section computed tomography images of the center of the femoral head, by using magnetic resonance imaging (MRI) to classify types of the natural course in non-collapsed ONFH.

Methods: This research included 102 hips with non-collapse ONFH.

Which Radiographic View Visualizes the Initial Collapse in Osteonecrosis of the Femoral Head? A Computed Tomography Scan Study.

Background: An accurate diagnosis for staging osteonecrosis of the femoral head (ONFH), particularly in early-stage collapse, is essential for determining therapeutic strategies. Various radiographic views in different femoral positions have been used to detect femoral head collapse. However, previous studies have not established the optimal femoral position that can sensitively detect initial collapse on plain radiography.

Increasing Prevalence and Risk Factors for Multifocal Osteonecrosis in Patients Who Have Corticosteroid-Associated Osteonecrosis of the Femoral Head: A 15-Year Multicenter Study.

Background: Multifocal osteonecrosis (MFON) is a rare condition affecting multiple bone sites, with limited epidemiological data available. This study investigated the frequency, trends, and risk factors for MFON in patients aged > 15 years who had corticosteroid-associated osteonecrosis of the femoral head (ONFH) using data from a multicenter sentinel monitoring system in Japan.

Methods: Data from 658 patients between 2009 and 2023 were analyzed.

Treatment of Long Coronavirus Disease in Japan: A Nationwide Study of Symptom-Associated Drug Prescriptions.

Long coronavirus disease (COVID) is characterized by symptoms persisting or reappearing at least 2 months post-recovery from acute coronavirus disease 2019 (COVID-19). Although Long COVID symptoms have been widely studied, data on drug prescriptions for patients with Long COVID in Japan remain limited. Therefore, this study aimed to analyze drug utilization patterns for Long COVID treatment using a nationwide database in Japan, with the goal of providing basic data to support the establishment of standard treatments in the future.

Articulating Materials Are Determinants of Survivorship of Hip Arthroplasties Performed for Nontraumatic Osteonecrosis of the Femoral Head.

A nationwide multicenter follow-up cohort study of hip-replacement arthroplasties performed for nontraumatic osteonecrosis of the femoral head (ONFH) was conducted to clarify factors associated with need for reoperation. We analyzed 7393 arthroplasties including 6284 total hip arthroplasties (THAs), 886 bipolar hemiarthroplasties (BPs), 188 total resurfacing arthroplasties, and 35 hemi-resurfacing arthroplasties (hRSs). The identified risk factors were combined systemic steroid use and excessive alcohol consumption (both ONFH-associated factors), a lateral approach, alumina BPs (aBPs), and hRSs, which were reported previously.

The use of porous titanium acetabular augments in primary total hip arthroplasty for hip dysplasia or rapidly destructive coxopathy.

Aims: This study aimed to evaluate the efficacy of porous titanium acetabular augments in primary total hip arthroplasty (THA) for reconstruction of superolateral acetabular bone defects in patients with Crowe II or higher classes of developmental dysplasia of the hip (DDH) or rapidly destructive coxopathy (RDC).

Methods: We conducted a retrospective evaluation of 27 patients (30 hips) who underwent primary THA using cementless cups and porous titanium acetabular augments. The follow-up periods ranged from two to 11 years, with a mean of 5.

Factors associated with dislocation after total hip arthroplasties performed for nontraumatic osteonecrosis of the femoral head: a multicenter cohort study of 5,983 hips.

Background And Purpose:  Nontraumatic osteonecrosis of the femoral head (ONFH) patients are at a higher dislocation risk after primary total hip arthroplasties (THAs) than osteoarthrosis patients. It has not been clear how large prosthetic heads should be to reduce dislocation. A nationwide multicenter follow-up cohort study of THAs performed for ONFH aimed to evaluate risk factors associated with dislocation and whether larger head size could reduce the dislocation risk.

A 5-Year Longitudinal Assessment of Quality of Life in Patients Who Have Osteonecrosis of the Femoral Head Undergoing Total Hip Arthroplasty: A Multicenter Study.

Background: The effects of surgical treatment on the quality of life (QOL) of patients who have osteonecrosis of the femoral head (ONFH) have been rarely reported. This multicenter study aimed to elucidate the longitudinal QOL in patients who have ONFH undergoing total hip arthroplasty.

Methods: Self-assessment QOL questionnaires, including the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ), Oxford Hip Score (OHS), and 12-Item Short-Form Health Survey Version 2 (SF-12v2), were administered to 124 patients at 6 months, 1 year, 2 years, and 5 years postoperatively.

Identification of Key Amino Acids in the A Domains of Polymyxin Synthetase Responsible for 2,4-Diaminobutyric Acid Adenylation in NBRC3020 Strain.

Developing novel nonribosomal peptides (NRPs) requires a comprehensive understanding of the enzymes involved in their biosynthesis, particularly the substrate amino acid recognition mechanisms in the adenylation (A) domain. This study focused on the A domain responsible for adenylating l-2,4-diaminobutyric acid (l-Dab) within the synthetase of polymyxin, an NRP produced by NBRC3020. To date, investigations into recombinant proteins that selectively adenylate l-Dab─exploring substrate specificity and enzymatic activity parameters─have been limited to reports on A domains found in enzymes synthesizing l-Dab homopolymers (pldA from USE31 and pddA from NBRC15115), which remain exceedingly rare.

Effects of Cerclage Cabling on Preventing Periprosthetic Femoral Fractures When Using Cementless Stems for Unstable Femoral Neck Fractures.

Background: Periprosthetic femoral fractures (PFFs) are serious complications in hip arthroplasty for femoral neck fractures. The rates of intraoperative (iPFFs) and postoperative PFFs (pPFFs) are higher in cementless stem cases than in cemented cases. This study aimed to investigate the effects of cerclage cabling on PFF prevention in cementless arthroplasty for femoral neck fractures.