Blood type O increased perioperative blood loss in total knee arthroplasty: a propensity score-based inverse probability of treatment weighting matched analysis.

Purpose: The aim of this study was to compare total perioperative blood loss in patients undergoing total knee arthroplasty (TKA) in different ABO blood types.

Methods: This study was approved by the Institutional Review Board of our hospital (IRB No. 1510) on 2 February 2015.

Does hip bone morphology differ depending on the presence of cam lesions in borderline developmental dysplasia of the hip?

Background: The purpose of this study was to divide patients with borderline developmental dysplasia of the hip (BDDH) into two groups according to the presence of Cam lesions, and compare radiographs related to bone morphology between them.

Methods: We retrospectively analyzed consecutive patients with BDDH who underwent hip arthroscopy (HA) or periacetabular osteotomy (PAO) at our institution between October 2013 and October 2019. The patients were classified into two groups according to the presence of Cam lesions.

Differential Impact of Concomitant Methotrexate and Glucocorticoids Dosages on Biologics and JAK Inhibitors: The ANSWER Cohort Study.

Aim: This multicenter retrospective study evaluated the differential impact of concomitant methotrexate (MTX) and glucocorticoids (GCs) administration by dosage on the effectiveness and safety of biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKi) in a real-world cohort of patients with rheumatoid arthritis, adjusting for clinical backgrounds variables.

Methods: The study included 3751 treatment courses (bDMARD- or JAKi-naïve cases, 48.9%; tumor necrosis factor inhibitors: 1668; tocilizumab [TCZ]: 865; abatacept [ABT]: 825; JAKi: 393).

Achieving a neutral hip-to-calcaneus axis in kinematically aligned total knee arthroplasty equalizes coronal hindfoot pressure balance at initial ground contact in the gait cycle.

Aims: Evaluating plantar pressure distribution and coronal lower limb alignment, including the hindfoot, using the hip-to-calcaneus axis, known as the ground mechanical axis (GA), is valuable in total knee arthroplasty (TKA). This study aimed to compare postoperative changes in plantar pressure distribution and lower limb alignment between mechanically aligned TKA (MA-TKA) and ground kinematically aligned TKA (gKA-TKA), targeting neutral GA.

Methods: After 1:1 propensity score matching, 35 pairs of patients with end-stage osteoarthritis of the knee, who underwent gKA-TKA and MA-TKA with similar preoperative disability between September 2019 and March 2022, were compared.

Quantitative Evaluation of Tendon Gliding Sounds and Their Classification Using Deep Learning Models.

This study aims to develop and evaluate a deep learning (DL) model for classifying tendon gliding sounds recorded using digital stethoscopes (Nexteto, ShareMedical, Japan, Nagoya). Specifically, we investigate whether differences in tendon excursion and biomechanics produce distinct acoustic signatures that can be identified through spectrogram analysis and machine learning (ML). Tendon disorders often present characteristic tactile and acoustic features, such as clicking or resistance during movement.

Amount of mechanical hip-knee-ankle (mHKA) angle correction by fixed-bearing medial UKA can be predicted using a new morphological assessment method: the arithmetic hip-knee-ankle (aHKA) angle.

Introduction: The amount of change in coronal alignment by unicompartmental knee arthroplasty (UKA) is important when considering its long-term results. This study investigated whether the amount of change in mechanical hip-knee-ankle (mHKA) angle by medial fixed-bearing UKA can be predicted based on the arithmetic hip-knee-ankle (aHKA) angle, an indicator of bony nature that is independent of soft tissue balance.

Materials And Methods: The research involved 101 patients (125 knees) who underwent medial fixed-bearing UKA with the spacer-block technique.

Valgus positioning of the femoral component does not compromise short-term clinical outcomes in fixed-bearing unicompartmental knee arthroplasty.

Purpose: In unicompartmental knee arthroplasty (UKA), the tibial component tends to be placed in a mildly varus position because of the expected improvement in stress distribution and load transfer across the tibia. With the spacer block technique in UKA, if a tibial osteotomy is performed in the varus position, the femoral component is placed in the valgus position. Therefore, this study aimed to evaluate the impact of valgus positioning of the femoral component on the short-term postoperative clinical outcomes in fixed-bearing UKA using the spacer block technique.

Rapid decline of male honey bees in summer: the potential impact of Japanese barn swallows on high male loss.

Given the population size of eusocial hymenopteran insects, particular emphasis is placed on evaluating the number of reproductive female individuals (queen). However, male production also accounts for a substantial part of the reproductive output of a colony. The number of breeding males in the mating population plays a vital role in the health of a colony and, ultimately, a population size by influencing the mating status of the queen.

Comparison of anti-inflammatory and anti-angiogenic effects of JAK inhibitors in IL-6 and TNFα-stimulated fibroblast-like synoviocytes derived from patients with RA.

Rheumatoid arthritis (RA) involves synovial tissue proliferation, inflammation, and angiogenesis, and contributes to joint destruction. Angiogenesis is a key therapeutic target for the treatment of RA, and Janus kinase (JAK) inhibitors have emerged as a promising therapy. In this study, we compared the inhibitory effects of five JAK inhibitors, including tofacitinib (TOF), baricitinib, peficitinib, upadacitinib, and filgotinib, on interleukin (IL)-6-induced inflammation in RA synovial tissues.

Distinct impact of RF and ACPA titre on the effectiveness and persistency of biologics and JAK inhibitors: The ANSWER cohort study.

Objectives: We aimed to identify the impact of rheumatoid factor (RF) or anticyclic citrullinated peptide antibody (ACPA) titres on the retention of biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKis) in patients with rheumatoid arthritis.

Methods: We retrospectively analysed 5312 courses of bDMARDs or JAKis from the ANSWER cohort. To calculate hazard ratios (HRs) for treatment discontinuation, we used multivariate Cox proportional hazards modelling, adjusted for potential confounders.

Evaluating ChatGPT's Performance in Classifying Pertrochanteric Fractures Based on Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association (AO/OTA) Standards.

Introduction Generative Pre-Training Transformer (ChatGPT) has become widely recognized for its capability to generate text, synthesize complex information, and perform a variety of tasks without requiring human specialists for data collection. The latest iteration, ChatGPT-4, is a large multimodal model capable of integrating both text and image inputs, rendering it particularly promising for medical applications. However, its efficacy in analyzing radiographic images remains largely unexplored.

The Influence of Knee Phenotypes Based on Coronal Plane Alignment of the Knee on Intraoperative Soft Tissue Balance and Clinical Outcomes: Comparison between Kinematically and Mechanically Aligned Total Knee Arthroplasty.

This study examined the impact of preoperative coronal plane alignment of the knee (CPAK) classification on intraoperative soft tissue balance and postoperative clinical outcomes in patients undergoing modified kinematically aligned (mKA) and mechanically aligned (MA) total knee arthroplasty (TKA). A total of 90 knees treated with mKA-TKA and 63 knees treated with MA-TKA were classified based on CPAK. After adjusting for confounding factors, intraoperative soft tissue balance, including varus/valgus balance and joint component gap, range of motion (ROM), and the 2011 Knee Society score (KSS), were compared 1 year postoperatively using one-way ANOVA.

Bone marrow mononuclear cell transplantation promotes bone healing via gap junction-mediated cell-cell interaction.

Aims: Bone marrow mononuclear cells (BM-MNCs) are a rich source of hematopoietic stem cells that have been widely used in experimental therapies for patients with various diseases, including fractures. Activation of angiogenesis is believed to be one of the major modes of action of BM-MNCs; however, the essential mechanism by which BM-MNCs activate angiogenesis remains elusive. This study aimed to demonstrate that BM-MNCs promote bone healing by enhancing angiogenesis through direct cell-to-cell interactions via gap junctions, in addition to a previously reported method.

A 5-Year Longitudinal Assessment of Quality of Life in Patients Who Have Osteonecrosis of the Femoral Head Undergoing Total Hip Arthroplasty: A Multicenter Study.

Background: The effects of surgical treatment on the quality of life (QOL) of patients who have osteonecrosis of the femoral head (ONFH) have been rarely reported. This multicenter study aimed to elucidate the longitudinal QOL in patients who have ONFH undergoing total hip arthroplasty.

Methods: Self-assessment QOL questionnaires, including the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ), Oxford Hip Score (OHS), and 12-Item Short-Form Health Survey Version 2 (SF-12v2), were administered to 124 patients at 6 months, 1 year, 2 years, and 5 years postoperatively.

Impact of femoral stem alignment on periprosthetic bone density in THA: a study of the Avenir Complete stem.

Introduction: Thigh pain, aseptic loosening, and failure after total hip arthroplasty has been reported. Therefore, this study examines the impact of femoral stem alignment on periprosthetic bone mineral density (BMD) in THA using the Avenir Complete cementless stem, focusing on the role of precise stem alignment in maintaining proximal femoral BMD.

Materials And Methods: Consecutive patients who received the Avenir Complete stem via mini anterolateral approach in the supine position between March 2019 and March 2022 were included.

is a potential therapeutic target for osteosarcoma: and evaluations using generated artificial osteosarcoma cancer stem cell‑like cells.

Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells.

Simultaneous bilateral total hip arthroplasty results in smaller Leg length discrepancy than staged bilateral procedures.

Introduction: The purpose of this study was to compare leg length discrepancies (LLD) between simultaneous and staged bilateral total hip arthroplasty (BTHA).

Materials And Methods: This retrospective cohort study included 150 consecutive patients who underwent BTHA (60 simultaneous and 90 staged BTHA). To adjust for preoperative patient characteristics between groups, 1:1 propensity score matching was performed based on age, sex, body mass index, American Society of Anesthesiologists Physical Status, Tönnis classification, Crowe classification, preoperative range of motion (flexion and abduction), LLD, and Harris Hip Score (HHS).

JAK inhibitors inhibit angiogenesis by reducing VEGF production from rheumatoid arthritis-derived fibroblast-like synoviocytes.

Introduction/objectives: JAK/STAT signaling inhibition exerts therapeutic effects on angiogenesis in rheumatoid arthritis (RA). However, whether the inhibitory effect differs among JAK inhibitors because of differing selectivity is unknown. Therefore, we compared the inhibitory effects of tofacitinib, baricitinib, peficitinib, upadacitinib, and filgotinib on angiogenesis.

Real-world study comparing the efficacy of Janus kinase inhibitors in patients with difficult-to-treat rheumatoid arthritis.

Objective: This study aimed to analyze the clinical efficacy of JAK inhibitors in difficult-to-treat rheumatoid arthritis (D2TRA) and non-D2TRA patients and evaluate the factors influencing their efficacy using real-world data.

Method: Here, 159 JAK inhibitor-treated patients with rheumatoid arthritis were categorized into D2TRA and non-D2TRA groups. Data including the Clinical Disease Activity Index (CDAI) at initiation and 6 months after drug administration, drug retention months, and reason for discontinuation due to toxic adverse events were collected.

The medullary cavity morphology of the proximal femur influences the fixation pattern of the rectangular tapered short stem in total hip arthroplasty.

Introduction: This study aimed to evaluate differences in the pattern of fixation with a rectangular tapered short stem (Fitmore stem) due to proximal femoral medullary cavity morphology based on periprosthetic bone mineral density (BMD) and radiological findings.

Materials And Methods: We analyzed 105 consecutive patients (Dorr type A, 18; Dorr type B, 66; Dorr type C, 21) who underwent total hip arthroplasty using a Fitmore stem. Periprosthetic BMD was measured using dual-energy X-ray absorptiometry from 1 to 24 months postoperatively and radiological analysis was performed.