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Objectives/hypothesis: Evaluation of the clinical outcomes after 6 months of treatment with a novel adjustable implant, the APrevent® Vocal-Implant-System (VOIS), in conjunction with medialization thyroplasty (MT) in patients with unilateral vocal fold paralysis.
Study Design: Prospective case series study at single tertiary referral center.
Methods: Preoperative and 1 week, 7 weeks, and 6 months postoperative glottal efficiency (maximum phonation time [MPT]), voice quality (including GRBAS-scores and acoustic parameters) and self-perceived voice-related handicap (voice handicap index [VHI-30]) were measured and analyzed, whereas type of vocal fold closure was evaluated and determined by flexible videolaryngoscopy based on Södersten and Lindestad classification (Wilcoxon signed-rank test).
Results: Thirteen patients underwent MT with VOIS under local anesthesia. Six months after surgery, the VHI-30 and MPT had improved from a preoperative mean of 75.0 ± 22.9 and 2.7 ± 2.1 s to a postoperative mean of 20.6 ± 19.7 and 6.3 ± 4.0 s, respectively. The mean GRBAS score improved from preoperative scores of G = 2.7, R = 2.6, B = 2.6, A = 2.2, and S = 2.0 to G = 0.3, R = 0.3, B = 0.2, A = 0.2, and S = 0.3 at 6 months postoperatively. Improved glottal closure was achieved in all patients (n = 13). Five patients received postoperative adjustment for the optimization of voice quality and glottal closure. No intra- or postoperative complications were observed. Significant improvements in acoustic parameters, including percentage jitter, percentage shimmer, and signal-to-noise ratio, were also observed after MT. All results were statistically significant (P < .05, Cohen's d > .8).
Conclusions: APrevent® VOIS-Implantation is a safe procedure with good voice outcomes. Postoperative adjustments can be performed smoothly to optimize voice quality and glottal closure.
Level Of Evidence: 3 Laryngoscope, 132:1622-1629, 2022.
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http://dx.doi.org/10.1002/lary.29958 | DOI Listing |
Am J Speech Lang Pathol
September 2025
Department of Surgery, University of Wisconsin-Madison.
Purpose: The aim of this study was to determine the age at which children with voice disorders can complete videostroboscopy, acoustic, and aerodynamic voice assessments. Factors predicting videostroboscopy tolerance were examined.
Method: A retrospective observational cohort design was used.
Biomater Biosyst
September 2025
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Introduction: The airway mucosa plays a crucial role in protection and various physiological functions. Current methods for restoring airway mucosa, such as myocutaneous flaps or split skin grafts, create a stratified squamous layer that lacks the cilia and mucus-secreting glands of the native columnar-lined airway. This study examines the application of various injectable biopolymers as active molecules for a potential approach to regenerating laryngeal epithelial tissue.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
September 2025
Department of Otolaryngology Head And Neck Surgery, Far Eastern Memorial Hospital, No. 21, Section 2, Nan-Ya South Road, New Taipei City, Taiwan.
Introduction: Anterior glottic webs are epithelium-covered fibrous tissue formations at the anterior commissure, leading to synechiae between the bilateral vocal folds. They manifest with symptoms ranging from hoarseness to airway obstruction. However, treating anterior glottic webs are challenging due to their high recurrence rates.
View Article and Find Full Text PDFJ Acoust Soc Am
September 2025
Department of Head and Neck Surgery, University of California, Los Angeles, 31-24 Rehab Center, 1000 Veteran Avenue, Los Angeles, California 90095-1794, USA.
The goal of this study was to understand the interaction between the voice source spectral shape, formant tuning, and fundamental frequency in determining the vocal tract contribution to vocal intensity. Computational voice simulations were performed with parametric variations in both vocal fold and vocal tract configurations. The vocal tract contribution to vocal intensity was quantified as the difference in the A-weighted sound pressure level between the radiated sound pressure and the sound pressure at the glottis.
View Article and Find Full Text PDFJ Voice
September 2025
Department of Speech and Language Therapy, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey. Electronic address:
Objectives: In individuals over 65, age is an essential factor in voice changes. Acoustic and aerodynamic norms guide clinicians in interpreting clinical voice assessment results. This study aimed to present aerodynamic-acoustic voice measurements in older individuals with no voice complaints.
View Article and Find Full Text PDF