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Objectives: In individuals over 65, age is an essential factor in voice changes. Acoustic and aerodynamic norms guide clinicians in interpreting clinical voice assessment results. This study aimed to present aerodynamic-acoustic voice measurements in older individuals with no voice complaints. It was also aimed to compare the objective voice parameters between different older age groups and genders.
Methods: Total of 70 participants from the young old (65-74 years), middle old (75-84 years), and old old age groups (>85 years) without voice complaints were included. Participants were recruited from a nursing home. Participants were asked to perform prolonged phonation of /a/, /s/, and /z/. The PRAAT program was used in the analysis.
Results: The mean aerodynamic-acoustic analysis results for the young, middle, and old-old age groups are presented, respectively. For maximum phonation time (MPT), it is 16.6, 11.18, and 7.56 seconds. For the s/z ratio, it is 1.03, 1.31, and 1.22. Fundamental frequency (F0) is 202.18, 193.37, and 229.13 for females and 150.44, 128.22, and 144.25 Hz for males. Standard deviation of fundamental frequency (SDF0) is 2.09, 8.88, and 6.34. Jitter percentage (jit%) is 0.48, 0.65, and 0.48. Shimmer percentage (shim%) is 2.64, 3.58, and 3.3. Harmonic-to-noise ratio (HNR) is 22.38, 20.95, and 20.88. The mean MPT score of the young-old group was significantly higher than those of the middle and old (P < 0.05). The mean SDF0 of the middle-old group was significantly higher than that of the young-old (P < 0.05).
Conclusions: The differences in the mean acoustic-aerodynamic voice parameters between age groups are thought to substantially reflect the characteristics of the physiological aging process with different acoustic variables at different periods. It was also found that the overall stability control in vocal fold vibration decreases with aging, as shown by changes in SDF0 and MPT.
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http://dx.doi.org/10.1016/j.jvoice.2025.08.027 | DOI Listing |
J Cell Mol Med
September 2025
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses to compare GADD45A expression in granulosa cells (GCs) between DOR patients and controls.
View Article and Find Full Text PDFJ Neuroimaging
September 2025
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Background And Purpose: Socioeconomic determinants of health impact childhood development and adult health outcomes. One key aspect is the physical environment and neighborhood where children live and grow. Emerging evidence suggests that neighborhood deprivation, often measured by the Area Deprivation Index (ADI), may influence neurodevelopment, but longitudinal and multimodal neuroimaging analyses remain limited.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, New South Wales, Australia.
Introduction: Risperidone is approved for behaviors and psychological symptoms of dementia (BPSD), despite modest efficacy and known risks. Identifying responsive symptoms, treatment modifiers, and predictors is crucial for personalized treatment.
Method: A one-stage individual participant data meta-analysis of six randomized controlled trials (risperidone: n = 1009; placebo: N = 712) was conducted.
BMC Womens Health
September 2025
Jhpiego, Islamabad, Pakistan.
Background: Evidence from multiple pilots and post-introduction scale-up initiatives have demonstrated that self-administered subcutaneous depot-medroxyprogesterone acetate (DMPA-SC) has potential to improve contraceptive continuation rates and expand contraceptive access to populations with limited utilization of facility-based health services. Only a few of these studies have been conducted in South Asian countries, and none where most contraceptive use is of non-hormonal methods that require limited to no contact with the health system, leaving policymakers in countries like Pakistan with limited context-specific evidence to guide decisions on whether, how, and for whom to introduce DMPA-SC.
Methods: A prospective cohort study will be conducted in 41 health facilities and surrounding communities in Punjab, Pakistan.
Reprod Health
September 2025
Department of Sexual and Reproductive Health including UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organization, Avenue Appia 20, 1211, Geneva, Switzerland.
Background: The COVID-19 pandemic disrupted the provision of sexual and reproductive health services, including contraceptive and family planning (FP) services. The World Health Organization conducted a multi-country study in India, Nigeria and Tanzania to assess the impact of the pandemic on the health system's capacity to provide contraceptive and FP services. In this paper, we share the results of a qualitative study aimed at understanding clients' perspectives at the primary healthcare level on accessing contraceptive services in COVID-19-affected areas in the three aforementioned countries.
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