Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
is one member of the sirtuin family proteins with NAD (NAD)-dependent histone deacetylase activity. In this study, we report that zebrafish is induced upon viral infection, and overexpression of suppresses cellular antiviral responses. Disruption of in zebrafish increases the survival rate upon spring viremia of carp virus infection. Further assays indicate that sirt7 interacts with irf3 and irf7 and attenuates phosphorylation of irf3 and irf7 by preventing tbk1 binding to irf3 and irf7. In addition, the enzymatic activity of sirt7 is not required for to repress IFN-1 activation. To our knowledge, this study provides novel insights into function and sheds new light on the regulation of and by attenuating phosphorylation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4049/jimmunol.2100318 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protective effects of inactivated SPIV vaccine in sea perch (Lateolabrax japonicas) by intraperitoneal injection and immersion immunization.
Fish Shellfish Immunol
September 2025
College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Nansha-South China Agricultural University Fishery Research Institute, Guangzhou, 511464, China. Electronic address:
Sea perch is one of the most important fish species farmed in China. However, the frequent outbreak of viral diseases induced by sea perch iridovirus (SPIV) always caused high mortality and heavy economic losses in sea perch aquaculture. Up to now, no effective countermeasures against SPIV infection have been established.
View Article and Find Full Text PDFIRF3 in viral infections: more than just triggering the interferon response.
Genes Immun
September 2025
Institut Pasteur, Université Paris Cité, Mouse Genetics Laboratory, Paris, France.
Interferon regulatory factor 3 (IRF3) is the first transcription factor activating the expression of type I interferons (IFN-I). It is present in the cytoplasm of most cell types under basal conditions and its activation by phosphorylation allows a rapid triggering of the IFN-I pathway in response to viral infection. This activation of IFN-I is amplified by IRF7, the other major IFN-I transcription factor which expression is induced, in most cell types, by the interferon response.
View Article and Find Full Text PDFAlternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection.
Cell Rep
August 2025
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Pharmacology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry, Biophysics and Chemical Biology Graduate G
Interferon regulatory factor 7 (IRF7) is a master transcriptional regulator of innate immunity. IRF7 binds as a homodimer, or heterodimer with IRF3, to promoters of type I interferons (IFN-Is) to drive their expression, which activates expression of antiviral genes. Here, we demonstrate that alternative splicing of the first intron within the coding region of human IRF7 is regulated across immune tissues and in response to immunologic stimuli.
View Article and Find Full Text PDFBAP1 as a predictive biomarker of therapeutic response to oncolytic vaccinia virus for metastatic renal cell carcinoma therapy.
Cancer Immunol Immunother
August 2025
Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Background: The therapeutic efficacy of oncolytic vaccinia virus (JX-594) has been demonstrated in metastatic clear cell renal cell carcinoma (ccRCC); however, only selected patients respond, and there are no predictive biomarkers for therapeutic response. We aimed to identify predictive biomarkers for JX-594 treatment and elucidate the underlying mechanisms.
Methods: Four cell line-derived xenograft (CDX) models were developed using representative ccRCC cell lines harboring common mutations.
Association of interferon regulatory factor 8 dysregulation with dry eye in Sjögren's syndrome.
Int J Ophthalmol
August 2025
The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing 400016, China.
Aim: To investigate the expression of interferon regulatory factors (IRFs) in peripheral blood mononuclear cells (PBMCs) of patients with Sjögren's syndrome-related dry eye (SSDE) and to explore their correlation with clinical features, dendritic cell activation, and serological indicators.
Methods: A total of 53 SSDE patients and 62 non-Sjögren's syndrome dry eye (NSSDE) patients were enrolled. Demographic and clinical data were collected, and comprehensive ophthalmic examinations were performed, including the ocular surface disease index (OSDI) questionnaires, Schirmer I test (SIT), tear break-up time (TBUT), corneal fluorescein staining score (CFS), and confocal microscopy (IVCM).