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Aneurysmal bone cysts are locally aggressive benign bone tumours with a high risk of recurrence. We describe a case in a 4-year-old girl, involving the right acetabulum. A direct posterior approach was used and the lesion ablated with curettage and local adjuvants with bone grafting. The cyst resolved swiftly with an uncomplicated recovery.
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http://dx.doi.org/10.1136/bcr-2021-245586 | DOI Listing |
BJR Case Rep
September 2025
Department of Orthopaedic Surgery, Yokohama Sakae Kyosai Hospital, Sakae-ku, Yokohama, Kanagawa 247-8581, Japan.
Aneurysmal bone cyst (ABC) is a locally destructive benign tumour-like condition of the bones with blood-filled cystic cavities. The talus is an extremely rare site for an ABC, with <20 reported cases till 2012 based on a PubMed database search. Aneurysmal bone cyst recurrence in the talus after curettage and bone grafting is extremely rare.
View Article and Find Full Text PDFBiomed Pharmacother
September 2025
Division of Endocrinology and Centre for Research in ASTHI, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Sclerostin, a key regulator of Wnt/β-catenin signaling, exhibits dual therapeutic potential in bone disorders: its inhibition promotes bone formation in osteoporosis, while its mimicry suppresses aberrant bone growth in osteoarthritis (OA). Using structural insights from NMR studies, we identified two sclerostin-derived peptides: SC-1 (an 18-mer) from loop 2, and SC-3 (a 14-mer) from loop 3. Molecular modeling showed that SC-1 binds to the first ectodomain of LRP6, potentially displacing sclerostin through competitive inhibition to activate Wnt signaling.
View Article and Find Full Text PDFJ Med Case Rep
August 2025
Nuclear Physicist, University Clinical Centre of Kosovo, Prishtina, Republic of Kosovo.
Background: Differentiating brown tumor due to primary hyperparathyroidism from a giant cell tumor remains a clinical challenge. Misdiagnosis may lead to inappropriate oncologic treatment and unnecessary surgical interventions.
Case Presentation: We report the case of a 52-year-old Caucasian white woman of Albanian ethnicity with multiple osteolytic bone lesions and a history of repeated orthopedic surgeries over 5 years.
Transfus Apher Sci
August 2025
Department of Orthopedics and Traumatology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey. Electronic address:
Aim: This study aims to evaluate the effectiveness of preoperative embolization in reducing intraoperative blood loss and transfusion requirements, as well as its impact on recurrence in patients with histopathologically confirmed aneurysmal bone cysts (ABCs).
Methods: A retrospective review was conducted on 107 patients who underwent surgical treatment for ABC at a tertiary oncology center between 2004 and 2023. Patients were grouped based on whether they received preoperative embolization (n = 50) or not (n = 57).
Ann Med Surg (Lond)
July 2025
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction: There are limited reports of C1 lateral mass reconstruction using a titanium mesh cage following the surgical removal of an aneurysmal bone cyst (ABC). We describe two uncommon and challenging cases of C1 ABC, highlighting the obstacles and complexities involved in selecting the appropriate approach for tumor resection, C1 stabilization, and reconstruction.
Case Discussion: A 12-year-old boy presented with 3 months of progressive upper cervical and occipital pain with no history of trauma.