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Objective: The first objective was to identify a method for early prediction of independent outdoor functional walking 1 yr after a traumatic spinal cord injury using the motor and sensory function derived from the International Standards for Neurological Classification of Spinal Cord Injury assessment during acute care. Then, the second objective was to develop a clinically relevant prediction rule that would be accurate, easy to use, and quickly calculated in clinical setting.
Design: A prospective cohort of 159 traumatic spinal cord injury patients was analyzed. Bivariate correlations were used to determine the assessment method of motor strength and sensory function as well as the specific dermatomes and myotomes best associated with independent outdoor functional walking 1 yr after injury. An easy-to-use clinical prediction rule was produced using a multivariable linear regression model.
Results: The highest motor strength for a given myotome (L3 and L5) and preserved light touch sensation (dermatome S1) were the best predictors of the outcome. The proposed prediction rule displayed a sensitivity of 84.21%, a specificity of 85.54%, and a global accuracy of 84.91% for classification.
Conclusions: After an acute traumatic spinal cord injury, accurately predicting the ability to walk is challenging. The proposed clinical prediction rule aims to enhance previous work by identifying traumatic spinal cord injury patients who will reach a mobility level that fosters social participation and quality of life in the chronic period after the injury.
To Claim Cme Credits: Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME.
Cme Objectives: Upon completion of this article, the reader should be able to: (1) Revise the different motor and sensory function assessment methods used for prognostication of walking after an acute traumatic spinal cord injury; (2) Identify clinical factors that are significantly associated with functional walking 1 yr after a traumatic spinal cord injury; and (3) Accurately estimate the likelihood of reaching independent outdoor functional walking in the chronic phase after an acute traumatic spinal cord injury.
Level: Advanced.
Accreditation: The Association of Academic Physiatrists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Association of Academic Physiatrists designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
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http://dx.doi.org/10.1097/PHM.0000000000001812 | DOI Listing |
Neurol Res
September 2025
Toxicology Research Center, AJA University of Medical Sciences, Tehran, Iran.
Background: Free radicals play a key role in spinal cord injury and curcumin has the potential to act as an antioxidant agent. Controlled delivery of curcumin can be achieved through encapsulation in bovine serum albumin to form nanoparticles, and acellular scaffold can bridge lesions and improve axonal growth in spinal cord injury.
Objective: In this study, we evaluated the antioxidant effects of the scaffold containing curcumin nanoparticles in the unilateral spinal cord injury model in male rats.
Br J Nurs
September 2025
Senior Bladder, Bowel and Stoma Care, Clinical Nurse Specialist and Nurse Prescriber, Hollister Ltd.
The aim of this case study is to illustrate the benefits of clean intermittent self-catheterisation (CISC) in individuals with multiple sclerosis (MS) who have incomplete bladder emptying. People with MS usually start to experience bladder symptoms 6-8 years after diagnosis, although some individuals experience symptoms from the time of diagnosis. MS is a condition of the central nervous system that affects the brain and spinal cord; the immune system attacks myelin, a substance that protects the nerve fibres, preventing messages travelling smoothly along the fibres to control the whole body, which includes the nerves that control the bladder.
View Article and Find Full Text PDFCNS Neurosci Ther
September 2025
School of Information and Communication Engineering, North University of China, Taiyuan, China.
Aims: Decoding the motor intention by electroencephalography to control external devices is an effective method of helping spinal cord injury (SCI) patients to regain motor function. Still, SCI patients have much lower accuracy in the decoding of motor intentions compared to healthy individuals, which severely hampers the clinical application. However, the underlying neural mechanisms are still unknown.
View Article and Find Full Text PDFJ Neuroimaging
September 2025
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.
Background And Purpose: Socioeconomic determinants of health impact childhood development and adult health outcomes. One key aspect is the physical environment and neighborhood where children live and grow. Emerging evidence suggests that neighborhood deprivation, often measured by the Area Deprivation Index (ADI), may influence neurodevelopment, but longitudinal and multimodal neuroimaging analyses remain limited.
View Article and Find Full Text PDFCurr Microbiol
September 2025
Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
This review article describes recent research advances in the relationship between spinal cord injury (SCI) and the gut microbiota and each other's inflammatory response. SCI is a serious neurological disease that directly damages physiological function. Recent studies have shown that SCI significantly affected the composition and function of the gut microbiota, and even caused intestinal inflammation.
View Article and Find Full Text PDF