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Researchers often study constructs that are conceptually and/or empirically related, but distinct (i.e., "sibling constructs"). In social-personality psychology, as well as psychology more generally, there is little guidance for how to deal with sibling constructs, which can result in researchers ignoring or mishandling them. In this article, we start by situating sibling constructs in the literature on the jingle-jangle fallacies. Then, we outline 10 conceptual and empirical criteria for determining the degree to which, and in what ways, constructs may share a sibling relationship, using self-esteem and grandiose narcissism as a running example. Finally, we discuss strategies for handling sibling constructs in a systematic and transparent way. We hope that the procedures described here will help social-personality psychologists identify sibling constructs, understand when and why they pose problems for their research, and adopt strategies that ameliorate their adverse effects.
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http://dx.doi.org/10.1177/10888683211047101 | DOI Listing |
Genes (Basel)
August 2025
Institute of Human Genetics, Faculty of Medicine, University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Background: L-2-hydroxyglutaric aciduria (L2HGA) is a rare autosomal recessive neurometabolic disorder caused by biallelic loss-of-function variants in the L-2-hydroxyglutarate dehydrogenase () gene, leading to accumulation of L-2-hydroxyglutarate in the brain and other tissues. While various variants have been reported, the pathogenic mechanism of specific variants remains unclear. In this study, we aimed to investigate the molecular consequences of the c.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Nankai University School of Medicine, Nankai University, Tianjin 300071, China.
Ankylosing spondylitis (AS) displays wide inter-patient variability that is not accounted for by HLA-B27 alone, suggesting that additional immune and metabolic modifiers contribute to disease severity. Using a genetically matched design, we profiled peripheral blood mononuclear cells from two brother pairs discordant for AS severity and one healthy brother pair. Strand-specific RNA-seq was analyzed with a family-blocked DESeq2 model, while untargeted metabolites were quantified using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS).
View Article and Find Full Text PDFmedRxiv
July 2025
Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
Autism spectrum disorders (ASDs) are genetically and phenotypically heterogeneous and the majority of cases still remain genetically unresolved. To better understand large-effect pathogenic variation, we generated long-read sequencing data to construct phased and near-complete genome assemblies (average contig N50=43 Mbp, QV=56) for 189 individuals from 51 families with unsolved cases of autism. We applied read- and assembly-based strategies to facilitate comprehensive characterization of mutations (DNMs), structural variants (SVs), and DNA methylation profiles.
View Article and Find Full Text PDFSports (Basel)
June 2025
Department of Didactics of Physical, Artistic and Music Education, Faculty of Education of Albacete, University of Castilla-La Mancha, 02071 Albacete, Spain.
Body image is understood as a social construction acquired over the years that is generated as people learn behaviors and relate to each other in the search of their own identity. The aim of this research is to identify the personal and contextual factors which may influence the positive social, negative social, and self-concept dimensions of the social construction of body image on boys and girls from fifth and sixth grades of Primary Education by developing a descriptive exploratory study. For the sample, 719 pupils of fifth grade and sixth grade from Primary Education were selected to develop this research; 373 of them were boys (51.
View Article and Find Full Text PDFGene
September 2025
Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guang
Insertion/deletion (InDel) polymorphisms show promising applications in the field of forensic genetics, such as ancestry inference and complex kinship identification. In the present study, we investigated the genetic polymorphisms and forensic parameters of Chinese Baoan group based on three panels, and explored the genetic connections between the Baoan group and 26 intercontinental reference populations. Based on simulated genotyping data constructed from allele frequencies of 150 loci, the study utilized the likelihood ratio (LR) method and identical by state (IBS) method to assess the system efficacy of different panels and identification of complex kinships with the increase in the number of genetic markers.
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