Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objectives: The objective of this meta-analysis is to evaluate the diagnostic value of serum Cystatin C in acute kidney injury (AKI) in neonates.
Sources: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and WanFang Database were searched to retrieve the literature related to the diagnostic value of Cystatin C for neonatal AKI from inception to May 10, 2021. Subsequently, the quality of included studies was determined using the QUADAS-2 tool. Stata 15.0 statistical software was used to calculate the combined sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Additionally, meta-regression analysis and subgroup analysis contributed to explore the sources of heterogeneity.
Summary Of The Findings: Twelve articles were included. The pooled sensitivity was 0.84 (95%CI: 0.74-0.91), the pooled specificity was 0.81 (95%CI: 0.75-0.86), the pooled PLR was 4.39 (95%CI: 3.23-5.97), the pooled NLR was 0.19 (95%CI: 0.11-0.34), and the DOR was 22.58 (95%CI: 10.44-48.83). The area under the receiver operating characteristic curve (AUC) was 0.88 (95%CI: 0.85-0.90). No significant publication bias was identified (p > 0.05).
Conclusions: Serum Cystatin C has a good performance in predicting neonatal AKI; therefore, it can be used as a candidate biomarker after the optimal level is determined by large prospective studies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432009 | PMC |
| http://dx.doi.org/10.1016/j.jped.2021.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Kidney Health and Gender-Affirming Hormone Therapy for Transgender and Gender Diverse Individuals.
Clin J Am Soc Nephrol
September 2025
VA Greater Los Angeles Health Care System, Department of General Internal Medicine, Department of Medicine.
This review examines the effects of gender-affirming hormone therapy (GAHT) on kidney health in transgender and gender diverse (TGD) populations, which face significant challenges in accessing medical care. GAHT, typically involves estrogen therapy for transgender women and transfeminine individuals, testosterone therapy for transgender men and transmasculine individuals, and therapy regimens for individuals who are nonbinary or identify with another gender not culturally assigned to their sex assigned at birth. Hormone therapy influences biomarkers such as creatinine and cystatin C, which are used in estimating glomerular filtration rate (eGFR).
View Article and Find Full Text PDFPredicted skeletal muscle index as a scalable marker for sarcopenia risk and mortality in older Chinese adults.
Front Med (Lausanne)
August 2025
Department of Nephrology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.
Background And Aims: Sarcopenia, characterized by age-related loss of muscle mass and function, increases adverse outcomes in older adults. The predicted skeletal muscle mass index (pSMI), derived from serum creatinine and cystatin C, may serve as a practical biomarker. This study evaluated pSMI's ability to predict sarcopenia and mortality in older Chinese adults.
View Article and Find Full Text PDFNicorandil in preventing contrast-induced nephropathy in patients undergoing cardiac catheterization procedures: a systematic review and meta-analysis.
Ann Med Surg (Lond)
September 2025
Department of Medicine, Kabul University of Medical Sciences, Kabul, Afghanistan.
Background: Contrast-induced nephropathy (CIN) remains a significant complication in patients undergoing coronary angiography (CAG) and percutaneous coronary intervention (PCI).
Methods: A comprehensive literature search was conducted across PubMed, MEDLINE, Embase, Google Scholar, and Web of Science up to May 2024 to identify randomized controlled trials (RCTs) evaluating the efficacy and safety of nicorandil in patients undergoing CAG or PCI. The primary outcome was CIN incidence, while secondary outcomes included, changes in serum creatinine, serum cystatin C, blood urea nitrogen (BUN), and estimated glomerular filtration rate (eGFR).
Association between low-grade inflammation and distal sensorimotor polyneuropathy in type 2 diabetes: a cross-sectional study.
BMC Neurol
September 2025
Department of Endocrinology, Wuming Hospital, affiliated with Guangxi Medical University, Nanning, Guangxi, China.
Background: As inflammatory processes may be involved in the pathogenesis of diabetic distal sensorimotor polyneuropathy (DSPN), the first aim of the present study was to determine the clinical characteristics of type 2 diabetes mellitus (T2DM) with distal sensorimotor polyneuorpathy (DSPN). Next goal was to investigate inflammatory biomarkers, insulin-like growth factor- 1 and lipid profile in these patients. Finally, we aimed to compare the renal function in these patients.
View Article and Find Full Text PDFThe nuclear export inhibitor selinexor improves kidney function in a rat model of focal segmental glomerulosclerosis.
Am J Physiol Renal Physiol
September 2025
Division of Nephrology and Clinical Immunology, RWTH University Clinic, Aachen, Germany.
Focal segmental glomerulosclerosis (FSGS) is a common glomerular pathology characterized by podocyte injury, which can lead to kidney failure. Among the factors contributing to podocyte damage are mutations in nuclear pore complexes (NPCs), which regulate nuclear-cytoplasmic transport of proteins and RNAs. Defective NPCs can accumulate in highly differentiated, non-dividing cells such as podocytes.
View Article and Find Full Text PDF