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http://dx.doi.org/10.1016/j.xjtc.2021.05.022 | DOI Listing |
Arch Microbiol
September 2025
College of Agriculture and Biology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, People's Republic of China.
Cystofilobasidium infirmominiatum, biotechnologically significant yeast, is increasingly garnering attention due to its superior ability to produce valuable carotenoids and lipids. Nonetheless, until now, the reference genome that governs the biosynthesis of carotenoids and lipids in C. infirmominiatum remains unreported.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain.
The mechanical properties of graphene are investigated using classical molecular dynamics simulations as a function of temperature T and external stress τ. The elastic response is characterized by calculating elastic constants via three complementary methods: (i) numerical derivatives of stress-strain curves, (ii) analysis of cell fluctuation correlations, and (iii) phonon dispersion analysis. Simulations were performed with two interatomic models: an empirical potential and a tight-binding electronic Hamiltonian.
View Article and Find Full Text PDFBrief Bioinform
August 2025
Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, Xiwu Road, Xincheng District, Xi'an 710004, China.
Accurate tumor mutation burden (TMB) quantification is critical for immunotherapy stratification, yet remains challenging due to variability across sequencing platforms, tumor heterogeneity, and variant calling pipelines. Here, we introduce TMBquant, an explainable AI-powered caller designed to optimize TMB estimation through dynamic feature selection, ensemble learning, and automated strategy adaptation. Built upon the H2O AutoML framework, TMBquant integrates variant features, minimizes classification errors, and enhances both accuracy and stability across diverse datasets.
View Article and Find Full Text PDFInt J Oral Implantol (Berl)
September 2025
Purpose: To compare the accuracy of static guided surgery using a pilot drill guide and dynamic guided surgery for dental implant placement.
Materials And Methods: Partially edentulous adult patients requiring implant placement were randomly assigned to either the static guided surgery group using a pilot drill guide or the dynamic guided surgery group. Digital implant planning was conducted using intraoral scans and CBCT with planning software to determine the optimal prosthetic position.
Drug Dev Res
September 2025
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, India.
The epidermal growth factor receptor (EGFR) is a common diver gene for lung cancer (NSCLC), which leads to an increasing death rate worldwide. This study reports the design, synthesis, and biological evaluation of triazole-clubbed pyrimidine derivatives (RDa-RDm) as potential anticancer agents. Thirteen compounds were synthesized and screened against the A549 lung cancer cell line.
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