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Hydrogels based on collagen/β-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxidant properties of the obtained hydrogels increased over the course of their incubation in culture media and were dependent on the concentration of tannic acid in the matrices. The obtained materials influenced dehydrogenase activity and the ATP level of pathogens. Additionally, the materials' extracts improved the HaCaT cells' viability. Therefore, the obtained hydrogels seem to be promising biocompatible materials which display antimicrobial properties.
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http://dx.doi.org/10.3390/polym13193412 | DOI Listing |
Food Chem X
August 2025
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin 300308, China.
In this study, tannic acid (TA) was applied to remodel the structure of quercetin-loaded oat globulin fibrils (UF-Que), to form novel fibril-based composite hydrogels (UF-Que-TA) to encapsulate Que. The hydrogels were prepared by varying the [TA]/[UF] ratio to investigate the impact of TA on gelation behavior, microstructure, molecular interactions, and stability of Que. Physicochemical results indicated that the incorporation of TA significantly enhanced the gel strength and promoted non-covalent interactions including hydrogen bonding, hydrophobic interactions, and ionic interactions.
View Article and Find Full Text PDFCurr Comput Aided Drug Des
September 2025
Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-II, Institutional Area, Greater Noida, U.P, 201306, India.
Introduction: The white water lily (Nymphaea alba) is a traditional medicinal plant recognized for its diverse array of bioactive properties. However, its potential in wound healing remains largely unexplored. This study aimed to evaluate the phytochemical profile, cytotoxicity, and wound healing efficacy of Nymphaea alba flower extract (NAFE) using both in vitro and in vivo models, as well as computational network analysis.
View Article and Find Full Text PDFBiomed Pharmacother
September 2025
NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia. Electronic address:
Indigenous Australians have long recognised and utilised the therapeutic potential of Australian native plants for generations to treat and manage various diseases. In recent years, these native plants have been explored in preclinical research for their chemical profiles and therapeutic properties for conditions such as skin disorders, colds and flu, various cancers, neurological disorders, metabolic syndrome, and other inflammatory conditions. Notable species studied include Kakadu plum, Davidson's plum, Burdekin plum, Illawarra plum, anise myrtle, lemon myrtle, lemon aspen, quandong, muntries, and Tasmanian pepperberry.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
College of Ethnic Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address:
Wound healing is often hindered by bacterial infection, oxidative stress, and bleeding. Traditional dressings cannot simultaneously regulate multiple microenvironments. To address the shortcomings of traditional dressings, this study constructed a dual-network photothermal responsive multifunctional hydrogel OBCTCu based on four natural ingredients, including Bletilla striata polysaccharide (BSP), chitosan (CS), tannic acid (TA), and Cu.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 210009, China.
Conductive hydrogels have revolutionized wearable electronics due to their biocompatibility and tunable properties. However, it remains a great challenge for hydrogel-based sensors to maintain both conductivity and mechanical integrity in harsh environments. Synergistic dynamic interactions provide a promising strategy to address this issue.
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