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http://dx.doi.org/10.1016/j.jid.2021.07.186 | DOI Listing |
Front Vet Sci
August 2025
Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Altitude adaptation is a complex process involving multiple physiological and biochemical responses to hypoxia and other environmental stresses. In-depth genetic analysis of Tibetan sheep, which exhibit significant adaptations to high-altitude hypoxia, promises to elucidate hypoxia-tolerance mechanisms in plateau animals. Here, we conducted a genome-wide selection scan on three Tibetan sheep populations: low-altitude Tao (TS; 2887 m), medium-altitude Tianjun white (WT; 3331 m), and high-altitude Huoerba (HB; 4614 m).
View Article and Find Full Text PDFBr J Cancer
August 2025
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Background: Because breast cancer (BC) is molecularly heterogeneous, diagnosis and treatment will likely benefit from comprehensive genetic profiling. However, routine, high-resolution sequencing is not feasible yet, due to implementation challenges associated with whole-genome sequencing of formalin-fixed paraffin embedded (FFPE) BC samples. Therefore, we explored the potential of an alternative low-resolution, genome-wide testing approach that is able to capture the copy number (CN) landscape, including actionable alterations, in FFPE derived DNA.
View Article and Find Full Text PDFNPJ Precis Oncol
August 2025
Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
Identifying molecular drivers in triple-negative breast cancer (TNBC) is crucial. While HER2-low expression predicts response to novel antibody-drug conjugates, its biological influence on TNBC biology is unknown. We performed a comprehensive multi-omics analysis, integrating genomic, epigenomic, transcriptomic, and proteomic profiling to characterize HER2-low TNBC.
View Article and Find Full Text PDFCommun Biol
August 2025
Department of Biology, University of Naples Federico II, Naples, Italy.
Seed traits underlying germination, by determining the environment experienced by plants throughout their lifetime, can play a key role in shaping plants' adaptive strategies. However, the genomic bases of adaptation in seed traits and its link with local biotic and abiotic environments remain largely unexplored. Here, we used a pool-sequencing approach combining genome-wide association (GWA), genome-environment association (GEA) and a genome wide scan of a spatial genomic differentiation index (XX) to identify putative signatures of adaptation in seed traits and to climate and pollinator community across 14 populations of the wild plant species Brassica incana.
View Article and Find Full Text PDFPlants (Basel)
July 2025
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Key Lab of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Engineering Research Center of Chinese Medicine Resource, Ministry of Education,
Thunb. is a traditional Chinese medicinal herb whose floral buds are the primary source of pharmacological compounds that require manual harvesting. As a result, its floral bud duration, determined by the opening time, is a key determinant of both quality and economic value.
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