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Article Abstract
Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the antiobesity efficacy of WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that WIKIM31 can be used as a potential therapeutic probiotic for obesity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705947 | PMC |
| http://dx.doi.org/10.4014/jmb.2107.07024 | DOI Listing |
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