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A novel intermolecular system D-π⋯π'-A was constructed with tetraphenylethylene (TPE) and borondipyrromethene (BODIPY), which had a synergistic effect on PDT and PTT (1 + 1 > 2). The PTT effect of TPD-BOA(D/A) was 1.7 times the sum of BOA + TPD; the effect of PDTAD was 1.45 times the sum of TPA + BOD.
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http://dx.doi.org/10.1039/d1cc04481h | DOI Listing |
Int J Nanomedicine
September 2025
Department of Ultrasonic Imaging, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, People's Republic of China.
Background: Due to the complex structure and variable microenvironment in the progression of bladder cancer, the efficacy of traditional treatment methods such as surgery and chemotherapy is limited. Tumor residual, recurrence and metastasis are still difficult to treat. The integration of diagnosis and treatment based on nanoparticles can offer the potential for precise tumor localization and real-time therapeutic monitoring.
View Article and Find Full Text PDFChem Commun (Camb)
September 2025
Department of Chemistry, University of Zurich, 8057 Zurich, Switzerland.
Phototherapeutic methods like photodynamic therapy (PDT), photothermal therapy (PTT) and photodecaging have emerged as promising modalities for cancer treatment. Phototherapeutics are activated by light and thereby generate reactive oxygen species (ROS), heat, or release a caged, toxic carry-on. Their distinct advantages of spatial and temporal control preserve healthy tissue while promising a minimal invasive alternative to traditional therapeutic approaches.
View Article and Find Full Text PDFInt J Pharm
September 2025
Nanomedicine Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Medchal, Hyderabad 500078 Telangana, India. Electronic address:
Conventional cancer therapies, including surgery, chemotherapy, and radiotherapy, have achieved considerable clinical success but remain constrained by systemic toxicity, poor selectivity, drug resistance, and tumor recurrence. Photothermal therapy (PTT) and photodynamic therapy (PDT) have emerged as minimally invasive alternatives; however, their clinical translation is hindered by hypoxic tumor microenvironments, limited light penetration, and intratumoral heterogeneity. Recent advances in multifunctional nanoplatforms seek to overcome these limitations by integrating PTT and PDT with chemotherapy and immunotherapy, thereby enhancing therapeutic efficacy through synergistic mechanisms.
View Article and Find Full Text PDFThe escalating challenges associated with antibiotic resistance have posed formidable obstacles in the fight against microbial infections and the prevention of biofilm formation. To address this challenge, we developed PEB-COP-Cu, a low-cost, readily available copper-integrated covalent organic polymer (COP) with dual enzyme-like activities and intrinsic photoresponsiveness, to accelerate infected wound healing. This material was synthesized through the post-metallization process of a COF xerogel (PEB-COP), obtained a Michael addition elimination reaction, utilizing photoactive tetra-(4-aminophenyl)porphyrin (TAPP) and β-ketoenamine, specifically 1,3,5-tris(3-dimethylamino-1-oxoprop-2-en-yl)benzene (abbreviated as TDOEB), as the fundamental building blocks.
View Article and Find Full Text PDFPharmaceutics
August 2025
Department of Clinical Laboratory, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, Yancheng 224001, China.
: The rapid emergence of multidrug-resistant bacterial infections demands innovative non-antibiotic therapeutic strategies. Dual-modal photoresponse therapy integrating photodynamic (PDT) and photothermal (PTT) effects offers a promising rapid antibacterial approach, yet designing single-material systems with synergistic enhancement remains challenging. This study aims to develop uniform Cu-based metal-organic framework micrometer cubes (Cu-BN) for efficient PDT/PTT synergy.
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