Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
gutMGene (http://bio-annotation.cn/gutmgene), a manually curated database, aims at providing a comprehensive resource of target genes of gut microbes and microbial metabolites in humans and mice. Metagenomic sequencing of fecal samples has identified 3.3 × 106 non-redundant microbial genes from up to 1500 different species. One of the contributions of gut microbiota to host biology is the circulating pool of bacterially derived small-molecule metabolites. It has been estimated that 10% of metabolites found in mammalian blood are derived from the gut microbiota, where they can produce systemic effects on the host through activating or inhibiting gene expression. The current version of gutMGene documents 1331 curated relationships between 332 gut microbes, 207 microbial metabolites and 223 genes in humans, and 2349 curated relationships between 209 gut microbes, 149 microbial metabolites and 544 genes in mice. Each entry in the gutMGene contains detailed information on a relationship between gut microbe, microbial metabolite and target gene, a brief description of the relationship, experiment technology and platform, literature reference and so on. gutMGene provides a user-friendly interface to browse and retrieve each entry using gut microbes, disorders and intervention measures. It also offers the option to download all the entries and submit new experimentally validated associations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728193 | PMC |
| http://dx.doi.org/10.1093/nar/gkab786 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Brain-Gut-Microbiome Axis Across the Life Continuum and the Role of Microbes in Maintaining the Balance of Health.
J Integr Neurosci
August 2025
Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada.
There is a growing body of evidence that the interaction between various microbial organisms and the human host can affect various physical and even mental health conditions. Bidirectional communication occurs between the brain and the gut microbiome, referred to as the brain-gut-microbiome axis. During aging, changes occur to the gut microbiome due to various events and factors such as the mode of delivery at birth, exposure to medications (e.
View Article and Find Full Text PDFEffect of adding Georgi to feed on the microbial diversity in cattle feces.
Front Microbiol
August 2025
Institute of Animal Science, Ningxia Academy of Agriculture and Forestry, Yinchuan, Ningxia, China.
Introduction: Inflammation and oxidative stress can seriously endanger the health and growth of beef cattle. Georgi (SB) has significant anti-inflammatory and antioxidative effects. However, studies on the application of SB stems and leaves as roughage in animal husbandry are limited.
View Article and Find Full Text PDFA Novel Approach of T Cell Receptor Classification Reveals Dynamic Interactions Amongst Diet, Microbiota, and Host T Cells.
Immune Netw
August 2025
Department of Biological Science, Ajou University, Suwon 16499, Korea.
The intestinal immune system is adapted to maintain constant interactions with environmental stimuli without causing inflammation. The recognition of Ags derived from microbes and diet can induce Treg or effector T cell responses through dynamic regulatory mechanisms, significantly impacting host health and disease. Although several examples of Ag-specific T cell responses to microbial or dietary Ags have been reported, our understanding of the full range of gut T cell responses remains highly limited.
View Article and Find Full Text PDFBacteria-Mitochondria Cross-talk: How Microbes Regulate Mitochondrial Dynamics and Bioenergetics of Host Cells.
Infect Disord Drug Targets
August 2025
Department of Biochemistry and Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Mitochondria are the cellular powerhouses and are considered to be central to energy metabolism, dynamics, and homeostasis. There is growing evidence that the gut microbiome regulates mitochondrial biogenesis, dynamics (fission, fusion, mitoph-agy), and bioenergetics, and that it does so by connecting bacterial metabolites and signaling molecules. This review discusses the molecular mechanisms that underlie the interplay between bacteria and mitochondria, with a particular focus on the modulation of mitochondrial activities by microbial products, including bile acids, immunological mediators, and short-chain fatty acids (SCFAs).
View Article and Find Full Text PDFObstructive sleep apnea and the gut microbiota - mechanisms and opportunities.
Curr Opin Pulm Med
September 2025
Department of Emergency Medicine, 1 University of New Mexico, Albuquerque, New Mexico, USA.
Purpose Of Review: The relationship between obstructive sleep apnea (OSA) and the gut microbiota is increasingly recognized, yet the involvement of specific microbial taxa and the direction of causality remain unclear. This review synthesizes current evidence linking gut dysbiosis with disordered sleep, with a focus on OSA and its associated complications.
Recent Findings: Studies of alpha and beta microbial diversity in OSA patients, sampled at different sites, have had inconsistent results.