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Continuous monitoring of physical motion, which can be successfully achieved via a wireless flexible wearable electronic device, is essential for people to ensure the appropriate level of exercise. Currently, most of the flexible LC pressure sensors have low sensitivity because of the high Young's modulus of the dielectric properties (such as PDMS) and the inflexible polymer films (as the substrate of the sensors), which don't have excellent stretchability to conform to arbitrarily curved and moving surfaces such as joints. In the LC sensing system, the metal rings, as the traditional readout device, are difficult to meet the needs of the portable readout device for the integrated and planar readout antenna. In order to improve the pressure sensitivity of the sensor, the Ecoflex microcolumn used as the dielectric of the capacitive pressure sensor was prepared by using a metal mold copying method. The Ecoflex elastomer substrates enhanced the levels of conformability, which offered improved capabilities to establish intimate contact with the curved and moving surfaces of the skin. The pressure was applied to the sensor by weights, and the resonance frequency curves of the sensor under different pressures were obtained by the readout device connected to the vector network analyzer. The experimental results show that resonant frequency decreases linearly with the increase of applied pressure in a range of 0-23,760 Pa with a high sensitivity of -2.2 MHz/KPa. We designed a coplanar waveguide-fed monopole antenna used to read the information of the LC sensor, which has the potential to be integrated with RF signal processing circuits as a portable readout device and a higher vertical readout distance (up to 4 cm) than the copper ring. The flexible LC pressure sensor can be attached to the skin conformally and is sensitive to limb bending and facial muscle movements. Therefore, it has the potential to be integrated as a body sensor network that can be used to monitor physical motion.
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http://dx.doi.org/10.3390/mi12080976 | DOI Listing |
Phys Med Biol
September 2025
Institute for Instrumentation in Molecular Imaging (i3M), Consejo Superior de Investigaciones Cientificas, Camino de Vera s/n, Valencia, Valencia, 46022, SPAIN.
A key challenge in PET systems is collecting large amount of data with the most accurate information-time, energy, and position-to produce high-resolution images while limiting the number of channels to reduce costs and improve data collection efficiency. The new Ultra-High-performance Brain (UHB) scanner under development aims to tackle this issue, using a semi-monolithic detector that combines pixelated arrays and monolithic designs, along with signal multiplexing techniques. Approach.
View Article and Find Full Text PDFMed Phys
September 2025
Department of Biomedical Engineering, University of California at Davis, Davis, California, USA.
Background: High-resolution and high-sensitivity small-animal positron emission tomography (PET) scanners are essential non-invasive functional imaging tools in preclinical research. To develop small-animal PET scanners with uniform and high spatial resolution across the field-of-view, PET detectors capable of providing good depth-of-interaction (DOI) information are critical. Dual-ended readout detectors based on lutetium-yttrium oxyorthosilicate (LYSO) arrays with fine pitch represent a promising approach, wherein the choice of inter-crystal reflector significantly impacts the detector performance.
View Article and Find Full Text PDFVirology
September 2025
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang, China. Electronic address:
Colloidal gold technology has revolutionized viral diagnostics through its rapid, cost-effective, and user-friendly applications, particularly in point-of-care testing (POCT). This review synthesizes recent advancements, focusing on its role in detecting respiratory viruses, hepatitis viruses, and emerging pathogens. The technology leverages the unique optical and physicochemical properties of gold nanoparticles (AuNPs), including localized surface plasmon resonance (LSPR) and high surface-to-volume ratios, to achieve rapid antigen-antibody recognition with visual readouts within 15 min.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Orthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key
Clear aligners offer aesthetic and comfort advantages in orthodontics, yet their ability to deliver effective forces relies heavily on empirical judgment or large-scale optical scanning, lacking real-time quantitative evaluation. Integrating pressure sensors into aligners is a promising solution, but challenges in miniaturization, multi-dimensional sensing, measurement accuracy, and biocompatibility hinder clinical application. Here, an all-in-one Orthodontic Force Acquisition System (OFAS) is presented that enables real-time, 3D force monitoring using a cross-shaped iontronic sensing array and an origami-inspired, wireless battery-free readout circuit miniaturized for single-tooth placement.
View Article and Find Full Text PDFLab Chip
September 2025
Department of Electrical & Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong.
Traditional biophysical cytometry has been limited by its low-dimensional phenotyping characteristics, often relying on only one or a few cellular biophysical phenotypes as readouts. This has perpetuated the perception that biophysical cytometry lacks the power to determine cellular heterogeneity. Here, we introduce a multimodal biophysical cytometry platform, termed quantitative phase morpho-rheological (QP-MORE) cytometry, which simultaneously captures a collection of high-resolution biophysical and mechanical phenotypes of single cells at ultrahigh throughput (>10 000 cells per s).
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