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Molecularly imprinted polymers (MIP) consist of a molecular recognition technology with applicability in different areas, including forensic chemistry. Among the forensic applications, the use of MIP in biological fluid analysis has gained prominence. Biological fluids are complex samples that generally require a pre-treatment to eliminate interfering agents to improve the results of the analyses. In this review, we address the development of this molecular imprinting technology over the years, highlighting the forensic applications of molecularly imprinted polymers in biological sample preparation for analysis of stimulant drugs such as cocaine, amphetamines, and nicotine.
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http://dx.doi.org/10.1007/s00216-021-03596-x | DOI Listing |
Anal Chem
September 2025
Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province, School of Environmental Science and Engineering, Hainan University, Haikou 570228, China.
Sulfamethoxazole (SMX) is a widely used antibiotic with toxic and persistent residues, which poses potential health risks in aquatic environments. However, reliable and accurate detection is impeded by the nonspecific adsorption of interfering biomolecules in complex matrices. This study develops a molecularly imprinted photoelectrochemical (PEC) sensor based on BiOS/BiWO with excellent selectivity and antifouling properties.
View Article and Find Full Text PDFFood Res Int
November 2025
State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China. Electronic address:
Osteopontin (OPN), a multifunctional milk protein essential for bioactive functions, remains challenging to isolate efficiently due to the limited specificity of conventional methods. We developed hydrogel-based molecularly imprinted membranes (MIMs) for selective OPN recognition. Dimethylaminopropyl methacrylamide (DMAPMA) and N-isopropylacrylamide (NIPAM) were selected as functional monomers based on molecular docking and molecular dynamics (MD) simulations, ensuring optimized binding interactions.
View Article and Find Full Text PDFMikrochim Acta
September 2025
Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Ankara, Türkiye.
A novel molecularly imprinted polymer (MIP)-based electrochemical sensor has been developed for the selective detection of naringenin (NAR) in various real-world samples, including plant extracts, wine, and herbal supplements. To enhance the active surface area and porosity of the glassy carbon electrode (GCE), a 2D/0D nanocomposite composed of graphene oxide (GO) and cobalt ferrite (CFO) nanoparticles, CFO_GO, was incorporated into the sensor design. 4-aminobenzoic acid (4-ABA) was selected as the functional monomer to prepare the MIPs.
View Article and Find Full Text PDFAnal Methods
September 2025
College of Environmental Science and Engineering, Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Niversity Engineering Research Center of Watershed Protection and Green Development, Guilin University of Technology, Guilin, 541006, China.
The amplification of detection signals is an important method for improving the sensitivity of electrochemical detection. This study presents an efficient strategy for preparing electrochemical catalytic materials using a simple self-assembly technique to encapsulate Fe single atoms (Fe-SAs) and Ni single atoms (Ni-SAs) in the Cu-benzene-1,3,5-tricarboxylic acid (Cu-BTC) metal-organic framework to form a Cu-BTC@FeNi-SAs catalytic system. Subsequently, Cu-BTC@FeNi-SAs was modified on the surface of a gold electrode, and sulfadiazine was used as a template to prepare a molecularly imprinted polymer (MIP) on the modified electrode.
View Article and Find Full Text PDFTalanta
September 2025
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, 71526 Egypt. Electronic address:
Rutin is a potent antioxidant with therapeutic value in managing vascular and inflammatory conditions. Its accurate quantification is critical for pharmaceutical quality control and food safety. In this study, rutin was employed as a template to construct surface molecularly imprinted magnetic nanozymes (MIPs@FeO-CoNi).
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