98%
921
2 minutes
20
Background/aims: Hypoxemia in chronic obstructive pulmonary disease (COPD) leads to reduced ability to exercise, decreased quality of life, and, eventually, increased mortality. Home oxygen therapy in patients with severe COPD reduces distress symptoms and mortality rates. However, there have been few studies on physicians' prescription behavior toward home oxygen therapy. Therefore, we investigated the respiratory specialists' perspective on home oxygen therapy.
Methods: In this cross-sectional, study, a questionnaire was completed by 30 pulmonary specialists who worked in tertiary hospitals and prescribed home oxygen therapy. The questionnaire consisted of 28 items, including 15 items on oxygen prescription for outpatients, four for inpatients, and nine on service improvement.
Results: All physicians were prescribing less than 2 L/min of oxygen for either 24 (n = 10, 33.3%) or 15 hours (n = 9, 30.3%). All (n = 30) used pulse oximetry, 26 (86.7%) analyzed arterial blood gas. Thirteen physicians had imposed restrictions and recommended oxygen use only during exercise or sleep. Sixteen (53.3%) physicians were educating their patients about home oxygen therapy. Furthermore, physicians prescribed home oxygen to patients that did not fit the typical criteria for long-term oxygen therapy, with 30 prescribing it for acute relief and 17 for patients with borderline hypoxemia.
Conclusion: This study identified the prescription pattern of home oxygen therapy in Korea. Respiratory physicians prescribe home oxygen therapy to hypoxemic COPD patients for at least 15 hours/day, and at a rate of less than 2 L/min. More research is needed to provide evidence for establishing policies on oxygen therapy in COPD patients.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747924 | PMC |
http://dx.doi.org/10.3904/kjim.2020.470 | DOI Listing |
Photodiagnosis Photodyn Ther
September 2025
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
One of the key factors contributing to the poor prognosis of glioblastoma is the treatment resistance of glioma stem cells (GSCs). In this study, the efficacy of photodynamic therapy (PDT) using talaporfin sodium (NPe6), a second-generation photosensitizer, in combination with a semiconductor laser approved for clinical use in Japan was evaluated. The evaluation was performed in a patient-derived glioma stem cell (GSC) line, MGG8, which was established from human glioblastoma tissue.
View Article and Find Full Text PDFAdv Drug Deliv Rev
September 2025
State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, China; Department of Pharmacy, The Air Force Hospital of Eastern Theater Command, Nanjing 210002, China; Jiangsu Provincial Key Laboratory of Nano Technology, Medical School, Nanjing University,
Oxygen plays a critical regulatory role in tissue repair and regeneration. However, in the microenvironment of tissues with vascular damage, hypoxia is commonly present. This not only suppresses cell proliferation and differentiation but also delays angiogenesis and extracellular matrix reconstruction, ultimately hindering the tissue regeneration process.
View Article and Find Full Text PDFJ Colloid Interface Sci
September 2025
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China; Henan International Joint Laboratory of Smart Molecules and Identification and Diagnostic Functions, Henan Normal University, Xinxiang, Henan 453007, China. Electronic address:
Carbon monoxide (CO) has demonstrated significant potential in tumor therapy. However, the uncontrolled release of CO and single-modality therapy often fail to achieve the desired therapeutic outcomes. To address the above deficiencies, mesoporous silica nanoparticles containing tetrasulfide bonds (TMSNs) were constructed as intelligent nanocarriers to co-deliver a mitochondria-targeting photosensitizer (Au-TPP) and a photodynamically activated CO-releasing molecule (FeCO), enabling the synergistic combination of photodynamic therapy (PDT) and CO therapy.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
August 2025
Department of Orthopedics, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330006, China. Electronic address:
Infected wounds remain a major clinical challenge due to bacterial invasion, which disrupts the natural healing cascade through excessive reactive oxygen species (ROS) generation, severe vascular damage, and persistent inflammation. Inspired by the catechol-rich adhesive domains of mussel foot proteins, we developed an extracellular matrix (ECM)-mimetic polyethylene glycol (PEG) hydrogel incorporating polydopamine (PDA)-functionalized zinc oxide nanoparticles (ZnONPs) for infected wound therapy. The amino acid-functionalized PEG hydrogel reproduces ECM-like properties to facilitate cell migration and efficient exudate management; however, its lack of intrinsic antimicrobial activity limits therapeutic efficacy.
View Article and Find Full Text PDFJ Therm Biol
September 2025
Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
Objective: Breast cancer remains the most prevalent cancer among females globally, with an alarming rise in incidence. Conventional treatments like chemotherapy face several limitations, necessitating innovative approaches. In this study, the efficacy of a novel chemo-/sonodynamic/photothermal triune therapy utilizing paclitaxel-loaded gold nanoparticles (PTX@GNPs) for MCF-7 breast cancer cells treatment was explored.
View Article and Find Full Text PDF