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Objective: The Frontal Assessment Battery (FAB) is a neuropsychological tool largely used to assess executive functions. Prior studies found a marked ceiling effect for the prehension behavior subtest (PBT) in healthy and clinical populations. Aims of the present study were (i) to examine the psychometric properties of the FAB without the contribution of PBT and (ii) to provide normative data for a revised version of the FAB after exclusion of PBT (FAB15).
Methods: The normative sample included 1,187 healthy participants. PBT had near-zero variance, poor content validity, and no discrimination power. Internal consistency increased when PBT was excluded. We assessed the FAB15 factorial structure, interrater, and test-retest reliabilities. Normative data for the FAB15 were extracted through a regression-based procedure according to sex, age, and education.
Results: The principal component analysis revealed a single "executive factor" or alternatively a bifactorial solution reflecting the different degree of discriminative capability vs. difficulty of the subtests. The FAB15 demonstrated excellent interrater and test-retest reliabilities. Regression analysis showed that sex (lowly educated women < lowly educated men), higher age, and lower education affected FAB15 score. Accordingly, three grids for adjustment of raw scores (men, women, and both) were constructed. The cut-off was fixed at the non-parametric outer tolerance limit on the fifth centile (9.36, 95% CI).
Conclusion: The observation of a ceiling effect in healthy subjects makes PBT not suitable for inclusion in a neuropsychological battery. The FAB15 may successfully replace the conventional FAB as a more severe and valid short screening tool to assess executive functioning.
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http://dx.doi.org/10.1007/s10072-021-05544-0 | DOI Listing |
Bioinformatics
September 2025
The Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Motivation: Drug repositioning presents a streamlined and cost-efficient way to expand the range of therapeutic possibilities. Drugs with human genetic evidence are more likely to advance successfully through clinical trials towards FDA approval. Single gene-based drug repositioning methods have been implemented, but approaches leveraging a broad spectrum of molecular signatures remain underexplored.
View Article and Find Full Text PDFPLoS One
September 2025
Nationhood Lab, Pell Center for International Relations and Public Policy, Salve Regina University, Newport, Rhode Island, United States of America.
This study investigates the "First Settler Wellness Effect," exploring how cultural geography impacts traditional wellness (physical health, social relationships, and financial stability) and existential wellness (purpose, meaning, and community identity) across the United States. Using data from the Gallup-Healthways Well-Being Index, which includes responses from over 325,000 individuals across 110 Metropolitan Statistical Areas (MSAs) from 2009 to 2016, we analyze wellness outcomes through the lens of the American Nations Model. This model categorizes the United States into distinct cultural regions shaped by early settlement patterns, emphasizing the enduring influence of regional norms and ideologies.
View Article and Find Full Text PDFInt J Audiol
September 2025
Institute of Hearing Technology and Audiology, Jade University of Applied Sciences, Oldenburg, Germany.
Objective: Determination of monaural and binaural speech-recognition curves for the Freiburg monosyllabic speech test (FMST) in quiet to update and supplement existing normative data.
Design: Monaural and binaural speech-recognition tests were performed in free field at five speech levels in two anechoic test rooms at two sites (Lübeck and Oldenburg, Germany). For the monaural tests, one ear was occluded with a foam earplug.
Front Sports Act Living
August 2025
Moray House School of Education and Sport, ISPEHS, The University of Edinburgh, Edinburgh, United Kingdom.
The profile analyses the landscape of disability sport in Ghana, tracing its historical evolution and contemporary challenges. Alongside legislative advancements and the dedication of various stakeholders, an increase in the persons with disability population has been observed. Based on data from the Ghana Statistical Service census, this demographic rose from 737,743 in 2010 to 2,098,138 in 2021, constituting 3% and 8% of the Ghanaian population in those respective years.
View Article and Find Full Text PDFDiabet Med
September 2025
Augustana Faculty, University of Alberta, Camrose, Alberta, Canada.
Aims: In the general population, individuals who self-identify as girls and women are typically less active and report more barriers to physical activity (PA), often influenced by gender stereotypes and sociocultural norms. These barriers may be accentuated in individuals with type 1 diabetes (T1D), who face additional diabetes-related barriers to engaging in PA.
Methods: In this narrative review, electronic databases were searched using keywords related to PA barriers and T1D.