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Article Abstract
Background: Data regarding the association of antibody levels elicited after immunization with the BNT162b2 mRNA COVID-19 vaccine with epidemiological and clinical parameters are limited.
Methods: We prospectively measured the total (TAbs-RBD) and the neutralizing antibodies (NAbs-RBD) against the receptor binding domain (RBD) of SARS-CoV-2 spike protein in a cohort of 268 Healthcare workers before immunization, 20 days after the 1 dose and 30 days after the 2 dose of the BNT162b2 vaccine. A statistical analysis for possible association of antibodies' levels with epidemiological and clinical parameters was performed.
Results: The mean age (±SD) of the participants was 45.45 years (±11.93) (range: 24-70 years) and 211 (79.9%) were females. Statistically significant differences were detected regarding both TAbs-RBD and NAbs-RBD between the first and second doses of the vaccine (P < 0.001). The median (IQR) percentage (%) of NAbs-RBD after the 1 dose was 51.07% (31.60%) and after the 2 dose 95.31% (3.70%) (P < 0.001). The correlation between the TAbs-RBD and NAbs-RBD was after the 1 dose, Spearman's, rho: 0.861 (P < 0.001) and after the 2 dose rho: 0.989 (P < 0.001). Twenty days after the 1 dose, 56/264 (21.2%) of the participants had low levels of NAbs-RBD, while one month after the 2 dose all of them had protective levels of NAbs-RBD. After the 2 vaccine dose, a statistically significant negative association of TAbs-RBD was detected for age (P < 0.001), smoking (P = 0.011), and immunosuppressive medications (P < 0.001), while a positive association was detected for BMI (P = 0.004) and systemic adverse events after immunization (P = 0.001).
Conclusion: A significant correlation of TAbs-RBD and NAbs-RBD was detected after both vaccine doses. Older age, smoking, and immunosuppressive medications negatively affected the final antibody level after SARS-CoV-2 immunization. Our findings emphasize the significance of the 2 vaccine dose especially in the older age groups.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302834 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2021.07.067 | DOI Listing |
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