Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: The aim of the study was to assess the effects of chronic inflammation on incretin levels, inflammatory markers, and enteric neuronal function measured in isolated preparations of smooth muscle of rat.
Material And Methods: We induced experimental colitis using 2,4-dinitrobenzenesulfonic acid (DNBS) in 17 Albino male Sprague-Dawley rats, while 16 rats were used as a control. They were housed in temperature-controlled rooms in a 12-h light/dark cycle at 22-24°C and 50 to 60% humidity. We evaluated in both inflamed and healthy rats: fasting plasma glucose concentration, fasting plasma insulin, myeloperoxidase, active glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and GLP-2 levels, adiponectin, and C-reactive protein (CRP). We also evaluated colonic longitudinal smooth muscle contractile activity.
Results: Intrarectal administration of DNBS reduced body weight gain in inflamed rats. We recorded higher levels of fasting plasma glucose, and insulin in inflamed rats. We observed higher levels of myeloperoxidase and CRP, and lower levels of ADN in inflamed rats. We recorded higher levels of GIP, GLP-1, and GLP-2 in inflamed rats compared to the healthy ones. Regarding functional response of colon intestinal smooth muscle after electrical stimulation, we recorded a lower functional response of colon intestinal smooth muscle after electrical stimulation in inflamed rats.
Conclusions: We can conclude that chronic inflammation leads to an increase of incretin levels and to a decrease of functional response of colon intestinal smooth muscle after electrical stimulation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314401 | PMC |
| http://dx.doi.org/10.5114/aoms.2019.86704 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
US-triggered on-demand NO-releasing biomimetic nanoparticle to Remodel endothelial microenvironment for enhancing atherosclerosis-specific gas therapy.
Mater Today Bio
October 2025
Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China.
Atherosclerosis (AS) is a chronic inflammatory disease driven by endothelial dysfunction, vascular smooth muscle cell proliferation, and insufficient resolution of inflammation. Nitric oxide (NO) plays a crucial role in vascular homeostasis by promoting endothelial cell proliferation, maintaining endothelial integrity, suppressing smooth muscle cell hyperplasia, and exerting potent anti-inflammatory effects. However, clinical application of NO is hindered by its short half-life, lack of targeting, and uncontrolled release.
View Article and Find Full Text PDFLow-grade endometrial stromal sarcoma: a case report and literature review.
Front Oncol
August 2025
Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Background: Low-grade endometrial stromal sarcoma (LG-ESS) is a rare malignant tumor of the female reproductive system with atypical clinical symptoms and slow progression.
Case: A 44-year-old female with a history of intermittent severe dysmenorrhea, previous laparoscopic myomectomy, and uterine artery embolization (UAE) presented with rapidly enlarging pelvic masses. Imaging revealed uterine masses suggestive of leiomyomas, although an adnexal origin could not be excluded.
Associations Between Breast Implant Characteristics, Autoimmune Disease History, and Post-augmentation Symptom Reporting Among Puerto Rican Women.
Cureus
August 2025
School of Medicine, Universidad Central del Caribe, Bayamon, PRI.
Background Breast augmentation surgery (BAS) is one of the top cosmetic surgical procedures performed in the United States every year. There are various breast implant options, such as saline, silicone, smooth, and textured implants. Breast implant illness (BII) is a disorder associated with a wide array of symptoms presenting post breast implant surgery and is often associated with autoimmune disorders.
View Article and Find Full Text PDFTargeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells.
Cell Rep Med
September 2025
Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan 250012, China; Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong U
Abdominal aortic aneurysm (AAA) is a life-threatening condition lacking effective treatment. We investigate the role of the deubiquitinating enzyme USP21 in AAA development. Proteomic analysis reveals significant upregulation of USP21 in murine and human abdominal aortic tissues.
View Article and Find Full Text PDFThe ferroptosis-associated gene TIMP1 facilitates skin scar formation through the interaction with CST3 in fibroblasts.
Int Immunopharmacol
September 2025
Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi, China. Electronic address:
Skin scar formation is a critical pathological process in wound healing, but its underlying regulatory mechanisms remain incompletely elucidated. By integrating analyses of Bulk-RNA seq and single-cell RNA sequencing (scRNA-seq) data, we identified that ferroptosis-related biological processes potentially play a key role in skin scar formation. Further mechanistic studies demonstrated that in human dermal fibroblast cells, the ferroptosis regulator TIMP metallopeptidase inhibitor 1 (TIMP1) significantly promotes fibroblast differentiation toward a mature phenotype through interactions with cystatin C (CST3), characterized by upregulated expression of myofibroblast differentiation markers such as α-smooth muscle actin (α-SMA) and connective tissue growth factor (CTGF), along with enhanced cell proliferation and migration abilities.
View Article and Find Full Text PDF