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Sluggish Cognitive Tempo (SCT) has been less frequently studied in adolescents compared with school-aged youth, few studies have examined youth self-report of SCT, and no study has examined SCT in Italy. The present study examined the reliability and validity of the Child Concentration Inventory-Version 2 (CCI-2), a youth self-report measure of SCT, in 452 Italian adolescent high school students (37.8% female; mean age = 15.92 years). Adolescents were administered Italian translations of the CCI-2 and the attention deficit hyperactivity disorder (ADHD) Self-Report Scale (ASRS). School performance variables (i.e., teacher-rated grades and teachers' disciplinary ratings) were also collected. A random subsample ( = 88) of participants was also administered the Mackworth Clock Test, a short version of the Attention Network Test, and the Stop-Signal Task. In our study, all CCI-2 items showed adequate convergent-discriminant validity, and the CCI-2 scale score showed adequate internal consistency reliability. Confirmatory factor analysis results suggested the adequacy of a one-factor model of the CCI-2 items, which showed to be invariant across sex. Confirmatory factor analyses supported the dissociability of SCT from ADHD-Inattention and ADHD-Impulsivity. SCT was significantly and negatively associated with adolescents' average school grades, whereas ADHD was also significantly and negatively associated with adolescents' disciplinary ratings. In the random subsample, the CCI-2 total score was positively, significantly, and uniquely associated with overall reaction time on the Attention Network Task, but not other neurocognitive variables. This study provides further support for the reliability and validity of self-reported SCT in adolescence.
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http://dx.doi.org/10.1177/10731911211033349 | DOI Listing |
Turk J Pediatr
September 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Background: Glucocorticoids remain the primary treatment for acute lymphoblastic leukemia (ALL) in children. However, glucocorticoid-resistant ALL exhibits increased mortality rates. To overcome resistance and improve management strategies, alternative therapeutic agents are required.
View Article and Find Full Text PDFPediatr Infect Dis J
September 2025
From the Department of Pediatric Intensive Care Unit, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Background: Antiviral drugs and coronavirus disease 2019 (COVID-19) vaccines have significantly reduced COVID-19-related hospitalizations and deaths in infected children. However, COVID-19 continues to pose a major mortality risk in young children. High-sensitive cardiac troponin (Hs-cTn) is a specific marker of myocardial cell damage.
View Article and Find Full Text PDFIntegr Environ Assess Manag
September 2025
School of Public Health, Taipei Medical University, New Taipei City, 235040Taiwan.
Incorporating bioaccessibility into health risk assessments enhances the accuracy of exposure estimates for heavy metal (HM) pollution, supports targeted remediation, and informs public health and policy decisions, particularly for vulnerable populations. Because HM bioaccessibility depends on local soil and geographic characteristics, identifying its relationship with soil properties is crucial for assessing soil pollution potential. Although HM concentrations can be measured relatively easily, bioaccessibility requires complex laboratory procedures, limiting routine applications in regulatory contexts.
View Article and Find Full Text PDFAnesthesiology
October 2025
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background: Anesthetic exposure in young children raises concerns about neurodevelopmental safety, with preclinical evidence suggesting potential neurotoxicity of volatile anesthetics. This study aimed to assess whether the combination of dexmedetomidine and remifentanil, by reducing sevoflurane exposure, has any differential effect on neurodevelopmental outcomes in young children compared with sevoflurane alone.
Methods: This study was a prospective, double-blind, randomized clinical trial including children younger than 2 yr undergoing nonstaged, nonrepetitive surgeries.
Allergol Immunopathol (Madr)
September 2025
Department of Pulmonary Medicine, Rajasthan Hospital, Jaipur, India.
Saline nasal irrigation provides symptom relief in allergic rhinitis (AR), but the optimal saline concentration remains uncertain. The comparative efficacy of 3% hypertonic saline nasal irrigation (HSNI) versus 0.9% isotonic saline is still debated.
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