Development of an influenza pandemic decision support tool linking situational analytics to national response policy.

National influenza pandemic plans have evolved substantially over recent decades, as has the scientific research that underpins the advice contained within them. While the knowledge generated by many research activities has been directly incorporated into the current generation of pandemic plans, scientists and policymakers are yet to capitalise fully on the potential for near real-time analytics to formally contribute to epidemic decision-making. Theoretical studies demonstrate that it is now possible to make robust estimates of pandemic impact in the earliest stages of a pandemic using first few hundred household cohort (FFX) studies and algorithms designed specifically for analysing FFX data. Pandemic plans already recognise the importance of both situational awareness i.e., knowing pandemic impact and its key drivers, and the need for pandemic special studies and related analytic methods for estimating these drivers. An important next step is considering how information from these situational assessment activities can be integrated into the decision-making processes articulated in pandemic planning documents. Here we introduce a decision support tool that directly uses outputs from FFX algorithms to present recommendations on response options, including a quantification of uncertainty, to decision makers. We illustrate this approach using response information from within the Australian influenza pandemic plan.