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Personalised medicine is based on the principle that each body is unique and will respond to therapies differently. In cardiology, characterising patient specific cardiovascular properties would help in personalising care. One promising approach for characterising these properties relies on performing computational analysis of multimodal imaging data. An interactive cardiac imaging environment, which can seamlessly render, manipulate, derive calculations, and otherwise prototype research activities, is therefore sought-after. We developed the Cardiac Electro-Mechanics Research Group Application (CemrgApp) as a platform with custom image processing and computer vision toolkits for applying statistical, machine learning and simulation approaches to study physiology, pathology, diagnosis and treatment of the cardiovascular system. CemrgApp provides an integrated environment, where cardiac data visualisation and workflow prototyping are presented through a common graphical user interface.
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http://dx.doi.org/10.1016/j.softx.2020.100570 | DOI Listing |
Eur J Case Rep Intern Med
August 2025
Internal Medicine, University of California, Riverside School of Medicine, Riverside, USA.
Introduction: Pulmonary embolism (PE) is a life-threatening condition with well-defined management strategies; however, the presence of a clot-in-transit (CIT)-a mobile thrombus within the right heart-introduces a uniquely high-risk scenario associated with a significantly elevated mortality rate. While several therapeutic approaches are available-including anticoagulation, systemic thrombolysis, surgical embolectomy, and catheter-directed therapies-there is no established consensus on a superior treatment modality. Catheter-based mechanical thrombectomy has emerged as a promising, minimally invasive alternative that mitigates the bleeding risks of systemic thrombolysis and the invasiveness of surgery.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Introduction: Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a neuropsychiatric disorder with additional psychiatric features caused by NMDA-R immunoglobulin G (IgG) antibodies in cerebrospinal fluid (CSF). This report presents the follow-up of a patient in whom we assumed mild NMDA-R encephalitis in the first psychotic episode.
Case Study: A patient with a prior episode of an acute polymorphic psychotic syndrome relapsed five and a half years later following a severe COVID-19 infection.
Int J Nanomedicine
September 2025
Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, People's Republic of China.
Molecular imaging in nuclear medicine has been employed extensively in recent years for tumor-targeted diagnosis and treatment that is attributed to its non-invasive property, which enables visualized functional localization. This functionality relies on the development of radionuclide molecular probes designed with the objective of identifying specific targets on the surface of tumors. Epithelial cell adhesion molecules (EpCAM) are considered to be a promising target as an antigenic marker for its widely present and integral to the processes associated with tumor occurrence and progression.
View Article and Find Full Text PDFAnal Sens
January 2025
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 United States.
At present, two competing hyperpolarization (HP) techniques, dissolution dynamic nuclear polarization (DNP) and parahydrogen (para-H) induced polarization (PHIP), can generate sufficiently high liquid state C signal enhancement for in vivo studies. PHIP utilizes the singlet spin state of para-H to create non-equilibrium spin populations. In hydrogenative PHIP, para-H is irreversibly added to unsaturated precursors, typically in the presence of a homogeneous catalyst.
View Article and Find Full Text PDFJ Biomed Opt
September 2025
Leibniz University Hannover, Hannover Centre for Optical Technologies, Hannover, Germany.
Significance: Melanoma's rising incidence demands automatable high-throughput approaches for early detection such as total body scanners, integrated with computer-aided diagnosis. High-quality input data is necessary to improve diagnostic accuracy and reliability.
Aim: This work aims to develop a high-resolution optical skin imaging module and the software for acquiring and processing raw image data into high-resolution dermoscopic images using a focus stacking approach.