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To assess whether in-hospital infant formula supplementation impacts later successful breastfeeding among healthy mother-infant dyads in the United States who are not intending to exclusively use infant formula. Using secondary analysis of a national longitudinal survey (Infant Feeding Practices Study II, = 2,399), we estimated effects of in-hospital infant formula supplementation on later breastfeeding success by matching mothers whose infants received in-hospital formula supplementation with mothers whose infants did not. Estimates were compared across four matching methods. Outcomes of breastfeeding success included likelihood of following a sustained breastfeeding trajectory for the first year postpartum; feelings of favorability and postweaning; and breastfeeding intention, initiation, and duration for subsequent children. In-hospital formula supplementation halved the likelihood of following a breastfeeding trajectory characterized by sustained exclusive breastfeeding. Supplementation decreased feelings of favorability toward breastfeeding postweaning but did not impact the likelihood of . Supplementation did not impact intention to breastfeed a future child; it did, however, decrease the likelihood of breastfeeding initiation with a subsequent child by >66% and reduced average duration of breastfeeding any subsequent children by >6 weeks. A lack of experimental methodologies in previous studies makes it difficult to determine a causal link between infant formula in the hospital and less breastfeeding success. Assuming we have accounted for all appropriate confounders, this study provides evidence for such a causal link. Birth hospital policies and practices should speak of this risk of harm.
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http://dx.doi.org/10.1089/bfm.2020.0194 | DOI Listing |
J Allergy Clin Immunol Pract
September 2025
Department of Pediatric Allergy and Immunology, Ege University Faculty of Medicine, Izmir, Turkiye.
Background: In recent years, it has been argued that eosinophilic esophagitis (EoE) seen in the early period of oral immunotherapy (OIT) may also exist before OIT.
Objective: We sought to evaluate the presence of EoE before initiating OIT and identify risk factors (during fetal development, infancy, and environmental exposures) for its development.
Methods: 48 patients who underwent endoscopic evaluation before OIT were enrolled.
Food Res Int
November 2025
Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of Infant Formula Food, State Administration for Market Regulation, Harbin 150030, China. Electronic address:
Whey protein isolate (WPI) is an important food ingredient, but its high allergenicity limit its application. Recently, metal-phenolic networks (MPNs) have been shown to be effective in modifying proteins. The aim of this study was to evaluate the effects of MPNs formed from (-)-epigallocatechin-3-gallate (EGCG) and Fe on the structure, antibody-binding capacity, and functional properties of WPI.
View Article and Find Full Text PDFFood Res Int
November 2025
School of Food Science and Engineering, Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health, South China University of Technology, Guangzhou 510640, China; Sino-Singapore International Research Institute, Guangzhou 510555, China. Electronic address: zh
Breast milk is rich in bioactive proteins and oligosaccharides, including osteopontin (OPN) and 2'-fucosyllactose (2'-FL), which are believed to promote the growth of beneficial microbiota and regulate intestinal barrier function. In this study, fermentation substrates including DOPN (digested OPN fragment), 2'-FL and their combinations in varying proportions, were prepared through in vitro gastrointestinal digestion, dialysis and freeze-drying. Changes in gas production, organic acid levels, ammonia N concentration and bacterial population abundance were studied using an in vitro batch fermentation model, with feces inocula from healthy infants.
View Article and Find Full Text PDFEnviron Res
September 2025
Department of Environmental Health Engineering, Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
Concerns regarding the health implications of microplastics (MPs) pollution and their byproducts, such as bisphenol A (BPA) and phthalate esters (PAEs), have escalated, particularly for vulnerable populations like infants. Since infants are primarily nourished by breast milk or infant formula, their heightened exposure risk to these contaminants warrants investigation. This study assessed the presence, morphological characteristics, and associated byproducts (BPA and PAEs) of MPs in commercially available infant formulas sold in the Iranian market.
View Article and Find Full Text PDFJACC Case Rep
September 2025
Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.
Objective: To demonstrate a detailed procedural guide for right ventricular outflow tract (RVOT) stent placement for palliation of tetralogy of Fallot and pulmonary stenosis in a patient weighing <2 kg.
Key Steps: Obtain wire position with an 0.018-inch Hi-Torque floppy wire in a distal branch pulmonary artery.