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Polyvinyl chloride (PVC), polypropylene (PP), polyethylene (PE), and stainless steel (SS) are commonly used in medicine and food production technologies. During contact with microorganisms on the surface of these materials, a microbial biofilm is formed. The biofilm structure is difficult to remove and promotes the development of pathogenic bacteria. For this reason, the inhibition of biofilm formation in medical and food production environments is very important. For this purpose, five naturally occurring compounds were used for antimicrobial screening tests. The two with the best antimicrobial properties were chosen to inhibit the biofilm formation of and . After 3 days of exposure, thymol reduced the amount of biofilm of within the range of 70-77% and 52-75% for . Carvacrol inhibited the formation of biofilms by up to 74-88% for and up to 86-100% for . Those phenols decreased the enzyme activity of the biofilm by up to 40-100%. After 10 days of exposure to thymol, biofilm formation was reduced by 80-100% for and by about 79-100% for . Carvacrol reduced the amount of biofilm by up to 91-100% for and up to 95-100% for .
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http://dx.doi.org/10.3390/molecules26092723 | DOI Listing |
Am J Physiol Lung Cell Mol Physiol
September 2025
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Cystic Fibrosis (CF) is a multiorgan disease caused by mutations in the gene, leading to chronic pulmonary infections and hyperinflammation. Among pathogens colonizing the CF lung, is predominant, infecting over 50% of adults with CF, and becoming antibiotic-resistant over time. Current therapies for CF, while providing tremendous benefits, fail to eliminate persistent bacterial infections, chronic inflammation, and irreversible lung damage, necessitating novel therapeutic strategies.
View Article and Find Full Text PDFInt J Syst Evol Microbiol
September 2025
State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
The family , encompassing the genus and related taxa, comprises diverse Gram-negative, aerobic, rod-shaped bacteria found in varied habitats, including air, soil, water and glaciers. Recent genomic-based taxonomic revisions have reclassified some species into new genera, such as and , due to polyphyletic relationships within the family . Certain species are known for forming biofilms or functioning as aerobic anoxygenic phototrophic bacteria, traits that enhance resilience in extreme environments like the cryosphere.
View Article and Find Full Text PDFJ Appl Microbiol
September 2025
Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed-to-be-University), Pillaiyarkuppam, Pondicherry - 607 402, India.
Aim: To investigate the phenotypic and genomic features of three multidrug-resistant (MDR) clinical mucoid and non-mucoid uropathogenic Escherichia coli (UPEC) strains to understand their antimicrobial resistance, biofilm formation, and virulence in urinary tract infections (UTIs).
Methods And Results: The UPEC strains A5, A10, and A15 were isolated from two UTI patients. Phenotypic assays included colony morphology, antibiotic susceptibility, motility, and biofilm formation.
Int Microbiol
September 2025
Department of Microbiology, The University of Burdwan, Bardhaman, West Bengal, 713104, India.
Biofilm formation and other virulence phenotypes under quorum sensing regulation play a vital role in the pathogenicity of Aeromonas hydrophila, triggering the emergence of multi-drug resistance (MDR) which increases fish mortality, environmental issues, and economic loss in aquaculture, necessitating the discovery of novel drugs to bypass standard antibiotics. Here, quorum quenching (QQ) may be a sustainable anti-virulent approach. β-Lactamase enzyme obtained from Chromohalobacter sp.
View Article and Find Full Text PDFmBio
September 2025
Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) ESKAPE pathogens pose a significant global health threat due to their ability to evade antibiotics through intrinsic and acquired mechanisms. These bacteria, including , , , , , and species, evade antibiotics through intrinsic and adaptive mechanisms. Common strategies include capsule formation, biofilm, β-lactamase production, and efflux activity.
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