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Recent attempts at cooperating on climate change mitigation highlight the limited efficacy of large-scale negotiations, when commitment to mitigation is costly and initially rare. Deepening existing voluntary mitigation pledges could require more stringent, legally-binding agreements that currently remain untenable at the global scale. Building-blocks approaches promise greater success by localizing agreements to regions or few-nation summits, but risk slowing mitigation adoption globally. Here, we show that a well-timed policy shift from local to global legally-binding agreements can dramatically accelerate mitigation compared to using only local, only global, or both agreement types simultaneously. This highlights the scale-specific roles of mitigation incentives: local agreements promote and sustain mitigation commitments in early-adopting groups, after which global agreements rapidly draw in late-adopting groups. We conclude that focusing negotiations on local legally-binding agreements and, as these become common, a renewed pursuit of stringent, legally-binding world-wide agreements could best overcome many current challenges facing climate mitigation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131631 | PMC |
http://dx.doi.org/10.1038/s41467-021-23056-5 | DOI Listing |
Front Immunol
September 2025
Department of Thoracic Surgery, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.
Background: Lung cancer remains the leading cause of cancer-related mortality globally, primarily due to late-stage diagnosis, molecular heterogeneity, and therapy resistance. Key biomarkers such as EGFR, ALK, KRAS, and PD-1 have revolutionized precision oncology; however, comprehensive structural and clinical validation of these targets is crucial to enhance therapeutic efficacy.
Methods: Protein sequences for EGFR, ALK, KRAS, and PD-1 were retrieved from UniProt and modeled using SWISS-MODEL to generate high-confidence 3D structures.
Front Reprod Health
August 2025
Department of Social Care and Social Work, Manchester Metropolitan University, Manchester, United Kingdom.
The climate crisis jeopardizes human health and is one of the greatest threats to reproductive autonomy and human rights. Witnessing these threats, the Sexual and Reproductive Health and Rights and Climate Justice Coalition was formed in 2021 to advocate on the intersections between climate change and sexual and reproductive health, rights, and justice (SRHRJ). The Coalition's purpose is to leverage intersectional approaches to influence global and national policies, programs, and funding mechanisms to advance climate justice, gender equality, and human rights.
View Article and Find Full Text PDFThe distinction between civilians and combatants is central to international humanitarian law. Yet are there distinctions among civilians that scholars of international law and international relations should consider? On the basis of US military documents and practices, we argue that in the recent conflicts in Iraq and Afghanistan, a hierarchy of 'civilianness' (Sutton) emerged. This hierarchy was structured along three observable axes of differentiation: personal security, compensation for harm, and credibility.
View Article and Find Full Text PDFFront Genet
August 2025
Hunan Provincial Key Laboratory of Finance and Economics Big Data Science and Technology, Hunan University of Finance and Economics, Changsha, China.
RNA N4-acetylcytidine (ac4C) is a crucial chemical modification involved in various biological processes, influencing RNA properties and functions. Accurate prediction of RNA ac4C sites is essential for understanding the roles of RNA molecules in gene expression and cellular regulation. While existing methods have made progress in ac4C site prediction, they still struggle with limited accuracy and generalization.
View Article and Find Full Text PDFVet World
July 2025
Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat 80160, Thailand.
Background And Aim: The global shift toward antibiotic-free poultry production necessitates sustainable alternatives to conventional growth promoters. Hydrolyzable tannins (HTs) from plants have shown antimicrobial, antioxidant, and gut-modulatory effects, making them promising feed additives. However, reliance on imported tannins from temperate species limits access for tropical producers, especially in Thailand.
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