Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Recent efforts to classify subtypes of major depressive disorder marked by different psychophysiological indicators have identified blunted reward-related brain activation in gambling tasks as a characteristic linked specifically to depressed participants with impaired mood reactivity.
Methods: The current study compared individuals diagnosed with current depressive disorder (n = 26) with healthy controls (n = 24) regarding brain responses to gain and loss trials in an fMRI version of the "Doors" choice-feedback task. Study aims were to examine reward-related brain activation in relation to depression, depressive subtypes, and course of depression.
Results: Across the sample, participants showed a significant response to gain versus loss in left and right ventral striatum as well as medial and left lateral prefrontal cortex. Relative to controls, participants with current depression were characterized by blunted reactivity in left ventral striatum. Furthermore, activation in the left ventral striatum differentiated subgroups of depression with and without impaired mood reactivity. Finally, left striatal hypoactivation to reward predicted remission when controlling for current depressive symptomatology, albeit at a trend level.
Conclusions: Blunted reward-related activation in the left ventral striatum might be useful as a marker for depression subtype and may have the potential to predict future course of depression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pscychresns.2021.111298 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Suspected Bartholin gland cystic-like structure and associated in a 1-year-old Nigerian dwarf doe.
Can Vet J
September 2025
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn Alabama, USA (Schwartz, Waters, Cole, Forehand, Prim, Rush, Stockler); Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn Alabama, USA (Neto).
A 1-year-old intact Nigerian dwarf nulliparous doe was presented to the Auburn University College of Veterinary Medicine, Large Animal Teaching Hospital in March 2024 for evaluation of recurrent perivulvar masses of 3 mo duration. Transcutaneous ultrasonographic examination of the labia and ventrolateral peri-vulvar area was carried out. This examination revealed a horizontally oriented, bilobed mass on the dorsal left labia majora, and a separate mass located directly below the ventral vulvar commissure.
View Article and Find Full Text PDFHigh-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex.
Brain
September 2025
Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, 13005 Marseille, France.
The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the LPFC, our current understanding of connectivity profiles guiding these interventions based on electrophysiology remains limited. Here, we present a high-resolution probabilistic map of bidirectional effective connectivity between the LPFC and widespread cortical and subcortical regions.
View Article and Find Full Text PDFRight hemisphere language network plasticity in aphasia.
Brain
September 2025
Center for Brain Plasticity and Recovery, Center for Aphasia Research and Rehabilitation, Departments of Neurology and Rehabilitation Medicine, Georgetown University Medical Center, Washington, DC, 20057 USA.
The role of the right hemisphere in aphasia recovery has been controversial since the 19th century. Imaging studies have sometimes found increased activation in right hemisphere regions homotopic to canonical left hemisphere language regions, but these results have been questioned due to small sample sizes, unreliable imaging tasks, and task performance confounds that affect right hemisphere activation levels even in neurologically healthy adults. Several principles of right hemisphere language recruitment in aphasia have been proposed based on these studies: that the right hemisphere is recruited primarily by individuals with severe left hemisphere damage, that transcallosal disinhibition results in recruitment of right hemisphere regions homotopic to the lesion, and that increased right hemisphere activation diminishes to baseline levels over time.
View Article and Find Full Text PDFCase Report: Multidimensional Analgesia via Asymmetric Dual-Target Deep Brain Stimulation of the Periaqueductal Gray and Ventral Posterior Thalamus in Central Post-stroke Pain.
Neurol Ther
September 2025
Department of Neurosurgery, The General Hospital of Western Theater Command, Chengdu, China.
Central post-stroke pain (CPSP) is an intractable neuropathic pain syndrome. Dual-target deep brain stimulation (DBS), which integrates sensory thalamic modulation and endogenous analgesic pathways, has emerged as a potential intervention; however, clinical evidence remains scarce. We report a 54-year-old woman who developed right-sided limb paresthesia progressing to persistent right hemibody pain following a left thalamic hemorrhage.
View Article and Find Full Text PDFPsychotic-like experiences in adolescents enriched for high-risk for developing severe mental illness: change over two-years and associations with neural reward processing and affective symptoms.
Eur Arch Psychiatry Clin Neurosci
September 2025
Department of Psychiatry, University of Pittsburgh, 121 Meyran Avenue, Pittsburgh, PA, 15213, USA.
Psychotic-like experiences (PLEs) -subclinical experiences or symptoms that resemble psychosis, such as hallucinations and delusional thoughts-often emerge during adolescence and are predictive of serious psychopathology. Understanding PLEs during adolescence is crucial due to co-occurring developmental changes in neural reward systems that heighten the risk for psychotic-related and affective psychopathology, especially in those with a family history of severe mental illness (SMI). We examined associations among PLEs, clinical symptoms, and neural reward function during this critical developmental period.
View Article and Find Full Text PDF