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http://dx.doi.org/10.1038/s41419-021-03779-5 | DOI Listing |
Circ Genom Precis Med
September 2025
Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, London, United Kingdom (W.J.Y., M.M.S., J.R., S.v.D., H.R.W., A.T., P.B.M.).
Background: There is a higher prevalence of heart rate corrected QT (QTc) prolongation in patients with diabetes and metabolic syndrome. QT interval genome-wide association studies have identified candidate genes for cardiac energy metabolism, and experimental studies suggest that polyunsaturated fatty acids have direct effects on ion channel function. Despite this, there has been limited study of metabolite concentration relationships with QT intervals.
View Article and Find Full Text PDFAnal Methods
September 2025
College of Science, Kunming University of Science and Technology, Kunming, 650500, China.
To address the technical challenges associated with determining the chronological order of overlapping stamps and textual content in forensic document examination, this study proposes a novel non-destructive method that integrates hyperspectral imaging (HSI) with convolutional neural networks (CNNs). A multi-type cross-sequence dataset was constructed, comprising 60 samples of handwriting-stamp sequences and 20 samples of printed text-stamp sequences, all subjected to six months of natural aging. Spectral responses were collected across the 400-1000 nm range in the overlapping regions.
View Article and Find Full Text PDFParasit Vectors
September 2025
School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Nat Commun
September 2025
Guangdong Provincial Key Laboratory of Bioengineering Medicine & National Engineering Research Center of Genetic Medicine, Department of Cell Biology and Institute of Biomedicine, Jinan University, Huang-Pu Avenue West 601, Guangzhou, 510632, China.