Article Synopsis
- Hallucinations in Parkinson’s disease (PD) are common non-motor symptoms that increase risks of psychosis and dementia.
- A new robotics-based method used conflicting sensorimotor stimulation to study presence hallucinations (PHs) in a specific subgroup of PD patients who respond strongly to these stimuli.
- The research identified a network in the brain associated with PHs, showing disruption in PD patients, which could predict symptoms and linked to cognitive decline, suggesting a correlation between severe PD and these complications.
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Article Abstract
Hallucinations in Parkinson's disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the induction of presence hallucinations (PHs) and the characterization of a subgroup of patients with PD with enhanced sensitivity for conflicting sensorimotor stimulation and robot-induced PH. We next identify the fronto-temporal network of PH by combining MR-compatible robotics (and sensorimotor stimulation in healthy participants) and lesion network mapping (neurological patients without PD). This PH-network was selectively disrupted in an additional and independent cohort of patients with PD, predicted the presence of symptomatic PH, and associated with cognitive decline. These robotics-neuroimaging findings extend existing sensorimotor hallucination models to PD and reveal the pathological cortical sensorimotor processes of PH in PD, potentially indicating a more severe form of PD that has been associated with psychosis and cognitive decline.
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| http://dx.doi.org/10.1126/scitranslmed.abc8362 | DOI Listing |
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