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The relevance of ionic liquids (ILs) is now well established in many fields, as their unique properties make them appealing as 1) greener alternatives to organic solvents (first-generation ILs), 2) tunable task-specific materials (second-generation ILs), and 3) multifunctional players in life and pharmaceutical sciences (third-generation ILs). This third wave of ILs encompasses a wide range of compounds, from bioactive molecules with single or even dual therapeutic action, to potential ingredient molecules for drug formulation and transport systems. In this context, the focus of this review is the emergent role of surface-active ionic liquids (SAILs) in drug development and delivery.
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http://dx.doi.org/10.1002/cmdc.202100215 | DOI Listing |
Bioresour Technol
September 2025
Department of Polymer Materials and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; Technology Innovation Center for High-Efficiency Utilization of Bamboo-Based Biomass in Guizhou Province, Guiyang 550025, China. Electronic address:
Worldwide, marine shell waste generated from the seafood industry has emerged as a significant environmental challenge. Indeed, this shell waste represents an abundant source of various valuable products, particularly chitin. However, the extraction and subsequent processing of chitin are hindered by the inherently resistant structure of these chitin-rich feedstocks, coupled with strong hydrogen bonding between chitin chains.
View Article and Find Full Text PDFFood Chem
September 2025
Henan International Joint Laboratory of Medicinal Plants Utilization, Colleage of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, Henan, China. Electronic address:
The bisphenols (BPs) contaminants with distinctive endocrine-disrupting properties have garnered significant attention. A new analytical methodology was proposed for the sensitive detection of hazardous BPs in efficient and food safety monitoring. The approach utilizes an ionic liquid-modified covalent organic framework (SCOF-V/IL-5F) as a solid-phase extraction adsorbent to enrich harmful BPs.
View Article and Find Full Text PDFJ Org Chem
September 2025
Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China.
An unprecedented recyclable system of copper-catalyzed C-C/N coupling of isatins and DMSO without any oxidant and acidic/basic additive has been unlocked. The -isatins occur tandem -methylation and C5-methylthiomethylation in order, while -substituted isatins proceed C5-methylthiomethylation only. DMSO serves as Me and MeSCH sources as well as the solvent.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Division of Nano Life Science, Kanazawa University, Kakuma-machi, 920-1192 Kanazawa, Japan.
Atomic force microscopy (AFM) imaging of ionic liquid (IL) distribution in electric double-layer (EDL) devices has been actively explored to understand the origin of their excellent performance. However, this has been impeded by insufficient resolution or a poor understanding of the mechanisms of 3D IL imaging. Here, we overcome these difficulties using 3D scanning force microscopy (3D-SFM) with variable tip/sample bias voltages for visualizing 3D ,-diethyl--methyl--(2-methoxyethyl)ammonium bis(trifluoromethanesulfonyl)imide (DEME-TFSI) distributions on a Au electrode in EDL capacitors.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Near-zero wear on engineering steel surfaces is a promising solution to extend the service life of mechanical equipment. However, most existing strategies offer only limited low wear under particular conditions and friction pairs. To address this, we design a polymer-based proton ionic liquid (PPILs) lubricant, leveraging the proton exchange between polyethylenimine, which is rich in active nitrogen groups, and bis(2-ethylhexyl) phosphate.
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