Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
While large-scale vaccination campaigns against SARS-CoV-2 are rolled out at the time of writing, non-pharmaceutical interventions (NPIs), including the isolation of infected individuals and quarantine of exposed individuals, remain central measures to contain the spread of SARS-CoV-2. Strategies that combine NPIs with innovative SARS-CoV-2 testing strategies may increase containment efficacy and help to shorten quarantine durations. We developed a user-friendly software tool that implements a recently published stochastic within-host viral dynamics model that captures temporal attributes of the viral infection, such as test sensitivity, infectiousness, and the occurrence of symptoms. Based on this model, the software allows to evaluate the efficacy of user-defined, arbitrary NPI and testing strategies in reducing the transmission potential in different contexts. The software thus enables decision makers to explore NPI strategies and perform hypothesis testing, e.g., with regard to the utilization of novel diagnostics or with regard to containing novel virus variants.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057763 | PMC |
| http://dx.doi.org/10.1016/j.patter.2021.100264 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis.
Cell Commun Signal
September 2025
Department of Cytology, Institute of Anatomy, Medical Faculty, Ruhr-University Bochum, Universitätsstr. 150, Building MA 5/52, Bochum, 44801, Germany.
Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by oxidative stress and progressive motor neuron degeneration. This study evaluates the potential neuroprotective effects of caffeine in the Wobbler mouse, an established model of ALS.
Methods: Wobbler mice received caffeine supplementation (60 mg/kg/day) via drinking water, and key parameters, including muscle strength, NAD metabolism, oxidative stress, and motor neuron morphology, were assessed at critical disease stages.
The influence of pure tacts and intraverbals on the transfer of verbal learning to new stimuli: Aan experimental study in children.
Learn Behav
September 2025
Departamento de Psicología, Facultad de Ciencias de la Educación y Psicología, Universidad de Córdoba, Calle San Alberto Magno, s/n, 14071, Córdoba, España.
This study investigates learning transfer processes in the teaching of pure tacts and intraverbals within the context of verbal behavior. The objectives were: to assess whether training pure tacts and intraverbals, through the inclusion of different stimuli, facilitates learning transfer to new impure tacts, and to determine whether one of these verbal operants (pure tact or intraverbal) better promotes learning transfer. The sample included 54 children aged 11-12 years, using a within-subjects experimental design with pre-post measures.
View Article and Find Full Text PDFAutoimmune encephalitis with Anti-mGluR1 antibodies: a comprehensive review.
J Neurol
September 2025
Department of General Practice, The First People's Hospital of Lin'an District, Hangzhou, Lin'an People's Hospital Affiliated to Hangzhou Medical College, Hangzhou, 310000, Zhejiang Province, China.
Anti-mGluR1 encephalitis is a rare autoimmune disorder manifesting with cerebellar syndrome with varying levels of severity. However, limited data exist regarding the clinical features and treatment strategies for patients suffering from encephalitis associated with anti-mGluR1 antibodies. Herein, we comprehensively review and discuss clinical features of anti-mGluR1 encephalitis to enhance our understanding of this rare disorder.
View Article and Find Full Text PDFFlexible suction-coagulation probe restores dexterity in robot-assisted surgery: bench-to-bedside evaluation.
Surg Endosc
September 2025
Department of Next Generation Endoscopic Intervention (Project ENGINE), Graduate School of Medicine, The University of Osaka, Suite 0802, BioSystems Bldg., 1-3, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Objective: Rigid suction-coagulation probes constrain the wrist-like articulation that is central to robotic surgery. We therefore designed a 5-mm single-use flexible suction ball coagulator (flex-SBC) with a modified core design to restore dexterity and assessed its mechanical performance and early clinical feasibility, including the effect of the common robotic gripping strategies on suction flow.
Methods: Preclinical.
Systematic variation of the acceptor electrophilicity in donor-acceptor-donor emitters exhibiting efficient room temperature phosphorescence suited for digital luminescence.
Commun Chem
September 2025
Dresden Integrated Center for Applied Physics and Photonic Materials (IAPP), Technische Universität Dresden, Dresden, Germany.
Purely organic materials showing efficient and persistent emission via room temperature phosphorescence (RTP) allow the design of minimalistic yet powerful technological solutions for sensing, bioimaging, information storage, and safety applications using the photonic design principle of digital luminescence. Although several promising materials exist, a deep understanding of the underlying structure-property relationship and, thus, development of rational design strategies are widely missing. Some of the best purely organic emitters follow the donor-acceptor-donor design motif.
View Article and Find Full Text PDF