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The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.
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http://dx.doi.org/10.1039/d1nr00309g | DOI Listing |
Pest Manag Sci
September 2025
State Key Laboratory Incubation Base for Green Processing of Chemical Engineering, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, People's Republic of China.
Background: Designing nanocarriers with specific biomimetic topological structures to enhance the frictional interaction of pesticides on the target plant leaves is an effective strategy to improve pesticide retention and utilization on plant foliage. However, complex and discontinuous nanocarrier preparation processes limit their large-scale production.
Results: Herein, we have successfully synthesized the uniform cocklebur-like silica nanoparticles (CSNs) using the flash nanoprecipitation (FNP) technique.
ACS Eng Au
August 2025
Department of Chemical and Biomolecular Engineering, Tandon School of Engineering, New York University, Brooklyn 11201, United States.
Polymeric microparticles (MPs) are valuable drug delivery vehicles for extended-release applications, but current manufacturing techniques present significant challenges in balancing size control with scalability. Industrial synthesis processes provide high throughput but limited precision, while laboratory-scale technologies offer precise control but poor scalability. This study explores Sequential NanoPrecipitation (SNaP), a two-step controlled precipitation process for polymeric microparticle production, to bridge the gap between laboratory precision and industrial scalability.
View Article and Find Full Text PDFDrug Deliv Transl Res
August 2025
School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, 47500, Selangor, Malaysia.
Lipid-polymer hybrid nanoparticles (LPN) are an integration or "collaboration" between the two distinct drug delivery platforms of lipid and polymeric carriers. The idea centres on coining the advantages of both materials while attempting to overcome the limitations inherent to each component, thus improving biocompatibility, drug loading, stability, size uniformity, and controlled release properties. Since their emergence over two decades ago, LPN have attracted growing interest in various therapeutic areas such as cancer, neurological disorders, osteoarthritis, and COVID-19 viral infections.
View Article and Find Full Text PDFCurr Drug Deliv
July 2025
Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Nanotechnology has transformed drug delivery systems, leading to the creation of various nanocarriers that offer significant advantages over traditional methods. This review explores key techniques and methods for producing nanocarriers like liposomes, niosomes, dendrimers, nanocapsules, carbon nanotubes, polymeric micelles, and solid lipid nanoparticles. Operating within the nanoscale range (1-100 nm), these nanocarriers enhance drug efficacy, reduce side effects, and improve bioavailability.
View Article and Find Full Text PDFDrug Dev Ind Pharm
August 2025
Department of Chemistry, Egerton University, Njoro, Kenya.
Objective: To provide a comprehensive evaluation of mucilage-based nanocarriers as emerging platforms for targeted cancer therapy, focusing on their design, functionalization, and therapeutic potential.
Significance: Mucilage, a plant-derived biopolymer composed of natural polysaccharides, possesses inherent biocompatibility, biodegradability, and unique physicochemical characteristics such as high-water retention, gel-forming ability, and stimuli-responsiveness. These properties position mucilage as an ideal material for controlled drug delivery in oncology, offering potential improvements over conventional nanocarriers.