Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection.

The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.

Optimisation and validation of a sensitive bioanalytical method for niclosamide.

The SARS-CoV-2 pandemic has spread at an unprecedented rate, and repurposing opportunities have been intensively studied with only limited success to date. If successful, repurposing will allow interventions to become more rapidly available than development of new chemical entities. Niclosamide has been proposed as a candidate for repurposing for SARS-CoV-2 based upon the observation that it is amongst the most potent antiviral molecules evaluated .

The effect of crude oil on arsenate adsorption on goethite.

This study reports the adsorption of arsenate, As(V), on goethite (α-FeO(OH)) and oil-coated goethite at experimental conditions chosen to mimic settings of wastewater from oil fields being released into marine and freshwater bodies. Similarities are evident between the As(V)-goethite and As(V)-oil-goethite systems: i) Adsorption is fast and saturation is achieved within 180 min, ii) Reaction rates approximate to a pseudo second order rate expression and range between 6.5 and 52.