Prognostic significance of family in multiple myeloma.

Multiple myeloma (MM) is a hematologic tumor with monoclonal proliferation of malignant plasma cells in the bone marrow. Fascin (FSCN) is an actin-binding protein that plays a crucial role in cell migration and invasion, contributing to tumor metastasis. There are three members () in family However, the prognostic role of family in MM remains unclear. In this study, we used four independent Gene Expression Omnibus (GEO) datasets to explore the relationships between expression profiles and patient survival in MM. We found that was dramatically down-regulated in MM compared to normal donors ( < 0.001) and monoclonal gammopathy of undetermined significance (MGUS) ( = 0.032). Patients with high expression of and had significantly longer OS ( = 0.023 and 0.028, respectively). Univariate and multivariate analysis showed that ( = 0.003, 0.002) and ( = 0.018, 0.013) were independent favorable prognostic factors for OS in MM. Moreover, the combination of high expression of and could effectively predict both longer EFS ( = 0.046) and OS ( = 0.015). Our study suggested that and can be used as favorable biomarkers for predicting clinical outcomes in MM.