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Objective: To identify spine patients' barriers to appropriate postoperative opioid use, comfort with naloxone, knowledge of safe opioid disposal practices, and associated factors.
Methods: We preoperatively surveyed 174 spine patients about psychobehavioral barriers to appropriate opioid use, comfort with naloxone, and knowledge about opioid disposal. Multivariable logistic regression identified factors associated with barriers and knowledge (α = 0.05).
Results: Common barriers were fear of addiction (71%) and concern about disease progression (43%). Most patients (78%) had neutral/low confidence in the ability of nonopioid medications to control pain; most (57%) felt neutral or uncomfortable with using naloxone; and most (86%) were familiar with safe disposal. Anxiety was associated with fear of distracting the physician (adjusted odds ratio [aOR], 3.8; 95% confidence interval [CI], 1.1-14) and with lower odds of knowing safe disposal methods (aOR, 0.18; 95% CI, 0.04-0.72). Opioid use during the preceding month was associated with comfort with naloxone (aOR, 4.9; 95% CI, 2.1-12). Patients with a higher educational level had lower odds of reporting fear of distracting the physician (aOR, 0.30; 95% CI, 0.09-0.97), and those with previous postoperative opioid use had lower odds of concern about disease progression (aOR, 0.25; 95% CI, 0.09-0.63) and with a belief in tolerating pain (aOR, 0.34; 95% CI, 0.12-0.95).
Conclusions: Many spine patients report barriers to appropriate postoperative opioid use and are neutral or uncomfortable with naloxone. Some are unfamiliar with safe disposal. Associated factors include anxiety, lack of recent opioid use, and no previous postoperative use.
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http://dx.doi.org/10.1016/j.wneu.2021.03.066 | DOI Listing |
Antimicrob Steward Healthc Epidemiol
August 2025
Pharmacy Department, Blacktown Hospital, Blacktown, NSW, Australia.
Background: Effective antimicrobial stewardship (AMS) programs must address the needs of culturally and linguistically diverse (CALD) patients who often experience language barriers and varying cultural beliefs regarding antibiotics. They are at greater risk of receiving suboptimal or inappropriate care, yet guidance to support AMS practices for this population remains limited.
Aim: To investigate antibiotic knowledge, perspectives, and experiences of CALD patients.
Womens Health Issues
September 2025
Tufts University School of Medicine/Tufts Medicine, Boston, Massachusetts. Electronic address:
Background: More than 20% of cervical cancers are diagnosed in women older than 65 years. Guidelines recommend screening exit at age 65 for average-risk patients only if certain criteria are met, yet most women aged 64-66 years in the United States are inadequately screened. In this mixed methods study, we explored clinician knowledge of exit criteria.
View Article and Find Full Text PDFDiabet Med
September 2025
Augustana Faculty, University of Alberta, Camrose, Alberta, Canada.
Aims: In the general population, individuals who self-identify as girls and women are typically less active and report more barriers to physical activity (PA), often influenced by gender stereotypes and sociocultural norms. These barriers may be accentuated in individuals with type 1 diabetes (T1D), who face additional diabetes-related barriers to engaging in PA.
Methods: In this narrative review, electronic databases were searched using keywords related to PA barriers and T1D.
JMIR Res Protoc
September 2025
Moores Cancer Center, University of California, San Diego, La Jolla, CA, United States.
Background: Cancer screening nonadherence persists among adults who are deaf, deafblind, and hard of hearing (DDBHH). These barriers span individual, clinician, and health care system levels, contributing to difficulties understanding cancer information, accessing screening services, and following treatment directives. Critical communication barriers include ineffective patient-physician communication, limited access to American Sign Language (ASL) cancer information, misconceptions about medical procedures, insurance navigation difficulties, and intersectional barriers for multiply marginalized individuals.
View Article and Find Full Text PDFACS Synth Biol
September 2025
Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710127, China.
The environmental resistance exhibited by microorganisms is concerned with their ability to withstand and adapt to an array of detrimental environmental conditions, with their survival and reproductive success being threatened. Within the realm of biotechnology, which emphasizes stress resistance, a critical role in bacterial adaptive strategies to environmental fluctuations is assumed to be in the periplasmic space. An innovative methodology to augment bacterial tolerance to stress by employing a mucin-mimetic collagen analogue, designated as S1552 (which is secreted into the periplasmic compartment), is introduced by this investigation.
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