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Article Abstract
: Childhood cancer survivors (Ccs) are at risk for cognitive late-effects, which might result from cortical alterations, even if cancer does not affect the brain. The study aimed to examine gray and white matter volume and its relationship to cognition. : Forty-three Ccs of non-central nervous system cancers and 43 healthy controls, aged 7-16 years, were examined. Cognitive functions and fine motor coordination were assessed and T1-weighted images were collected for voxel-based morphometry. : Executive functions ( = .024, = .31) were poorer in Ccs than controls, however still within the normal range. The volume of the amygdala ( = .011, .117) and the striatum ( = .03, .102) was reduced in Ccs. No significant structure-function correlations were found, neither in patients nor controls. : Non-CNS childhood cancer and its treatment impacts on brain structures relevant to emotion processing.
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| http://dx.doi.org/10.1080/17518423.2021.1898059 | DOI Listing |
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