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Article Abstract
Crop breeding for resistance to pathogens largely relies on genes encoding receptors that confer race-specific immunity. Here, we report the identification of the wheat Pm4 race-specific resistance gene to powdery mildew. Pm4 encodes a putative chimeric protein of a serine/threonine kinase and multiple C2 domains and transmembrane regions, a unique domain architecture among known resistance proteins. Pm4 undergoes constitutive alternative splicing, generating two isoforms with different protein domain topologies that are both essential for resistance function. Both isoforms interact and localize to the endoplasmatic reticulum when co-expressed. Pm4 reveals additional diversity of immune receptor architecture to be explored for breeding and suggests an endoplasmatic reticulum-based molecular mechanism of Pm4-mediated race-specific resistance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610370 | PMC |
| http://dx.doi.org/10.1038/s41477-021-00869-2 | DOI Listing |
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Article Synopsis
- Powdery mildew, caused by Blumeria graminis f. sp. tritici, is a highly destructive disease impacting wheat, particularly affecting common wheat, but durum wheat serves as a key resource for enhancement efforts.* -
- The study identified a durum wheat variety (DR88) with strong resistance to powdery mildew, localizing the dominant resistance gene, PmDR88, to a specific region on chromosome arm 2AL and confirming its association with the Pm4 locus through extensive genotyping.* -
- Despite PmDR88 sharing amino acid sequences with the Pm4d allele, it has distinct expression patterns; two complementary DNA markers were developed for efficient marker-assisted selection to integrate this