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Diabetic foot ulcer (DFU) is one of the common complications of diabetes. DFU can cause a huge medical and financial burden due to infections, compromise the quality of life, and increase the mortality rate in patients. However, the consumption of medical resources for DFU is rarely mentioned. A retrospective cohort study was performed. Data were obtained from the National Health Insurance Research Database of Taiwan, and the prevalence and medical utilization data for DFU in 2001-2015 were extracted, followed by the analysis for high-risk populations. Between 2001 and 2015, there were 7511 new DFU patients. A higher proportion in these patients was male, elderly with a low education level, and low income. Between 2001 and 2015, the prevalence of DFU was 0.5-0.8%, and the number of DFU patients showed stable growth. Every year, 12.6-19.3% and 1.2-7.0% of patients underwent debridement and amputation, respectively. The hospitalization fees increased year on year. Our study showed that the DFU prevalence increased year on year, and the DFU medical expenditure increased. DFU tends to occur in males, patients with low socioeconomic status, low education level, those with multiple comorbidities, and old age. Therefore, DFU care and prevention require the entire healthcare system to jointly formulate a prevention plan.
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http://dx.doi.org/10.3390/ijerph18041891 | DOI Listing |
Cureus
August 2025
General Surgery, Sree Balaji Medical College and Hospital, Chennai, IND.
Background Diabetic foot ulcers (DFUs) are a major complication of diabetes, posing significant challenges due to impaired wound healing, increased infection risk, and frequent need for surgical intervention. Optimal wound care is essential to reduce morbidity, hospital stay, and healthcare costs. While povidone iodine is a common antiseptic dressing, Metrogyl (metronidazole) targets anaerobic bacteria and may offer superior outcomes in chronic, infected wounds.
View Article and Find Full Text PDFFront Cell Dev Biol
August 2025
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.
Diabetic foot ulcers (DFUs) are a serious complication of diabetes, characterized by delayed wound healing, recurrent infection, and risk of amputation. Mitochondrial dysfunction has emerged as a central pathological mechanism underlying impaired wound healing. Persistent hyperglycemia triggers a cascade of mitochondrial abnormalities like disrupted calcium homeostasis, excessive ROS production, impaired autophagy, increased apoptosis, and imbalanced mitochondrial dynamics.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Orthopedics, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Diabetic foot ulcers (DFUs) represent a prevalent complication of diabetes, with a lifetime risk ranging from 15% to 25% among diabetic patients. Research indicates that anticoagulation plays a crucial role in the management of newly diagnosed cases of diabetic lower extremity atherosclerotic obliterative disease. However, in the present case, the patient developed dry gangrene in both toes after receiving vasodilator drugs during an emergency intervention for sudden aortic dissection.
View Article and Find Full Text PDFIndian J Endocrinol Metab
August 2025
Department of Histopathology, PGIMER, Chandigarh, India.
Introduction: Charcot neuroarthropathy (CNO) of foot characterised by an increased bone turnover denoted by serological markers of bone resorption. However, histological characteristics of foot bones in people with CNO are not well elucidated.
Methods: The foot bone samples were collected from patients who had either surgical reconstruction or below-knee amputations for chronic CNO foot ( = 10, Group A), unsalvageable diabetic foot ulcer ( = 16, Group B), and non-diabetic healthy controls following road traffic accident ( = 16, group C).
Diabetes Metab J
September 2025
Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Diabetic foot ulcer (DFU) represents a challenging complication of diabetes mellitus, characterized by slow healing processes. Protein kinase C delta (PKCδ) has been identified as a significant factor in the pathogenesis of various diabetic complications, including DFU. However, the precise underlying mechanisms remain to be fully elucidated.
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