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http://dx.doi.org/10.1038/s41416-021-01280-6 | DOI Listing |
J Heart Lung Transplant
September 2025
Department of Medicine, University of California, San Francisco, CA; Department of Anesthesia and the Cardiovascular Research Institute, University of California, San Francisco, CA.
J Clin Microbiol
September 2025
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Blood culture contamination (BCC) is a major healthcare challenge with no standardized process to monitor and report rates by individual healthcare facilities in the United States. A new study by V. Fabre, Y.
View Article and Find Full Text PDFJ Transl Med
September 2025
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, BO, Italy.
Endogenous transposable elements (TEs) are receiving increasing attention as potential targets to develop novel immunostimulatory strategies against cancer. Indeed, the defective epigenetic suppression of TEs in malignant cells offers a therapeutic window to enable their re-activation with at least some degree of selectivity. In line with this notion, multiple clinically employed epigenetic modifiers such as DNA-demethylating agents have been shown to promote the re-expression of TEs in preclinical tumour models, hence driving powerful inflammatory responses that enables increased sensitivity of immunitary immune cells to immunotherapy with immune checkpoint inhibitors (ICIs).
View Article and Find Full Text PDFActa Med Port
September 2025
Faculty of Medicine. Universidade de Lisboa. Lisbon. & Surgery Department. Unidade Local Saúde de Santa Maria. Lisbon. Portugal.
PLoS Biol
August 2025
Department of Pathology, University of California San Diego School of Medicine, La Jolla, California, United States of America.
The placenta is one of the most diverse organs among eutherian mammals, and comparative placentation studies can reveal fundamental processes that support a successful pregnancy. A new study in PLOS Biology uses swine placental organoids and in vivo spatial transcriptomics to uncover key insights into placental cell diversity and evolution.
View Article and Find Full Text PDF